7-Azabicyclo[2.2.1]heptane

Base Information

• Chemical Name: 7-Azabicyclo[2.2.1]heptane
• CAS No.: 279-40-3
• Molecular Formula: C6H11 N
• Molecular Weight: 97.16
• Hs Code.: 2933990090
• Mol file: 279-40-3.mol

Synonyms:7-Azanorbornane

Chemical Property of 7-Azabicyclo[2.2.1]heptane

Chemical Property:

• Vapor Pressure: 5.17mmHg at 25°C
• Boiling Point: 29℃ (26 Torr)
• PKA: 11.26±0.20(Predicted)
• Flash Point: 30.6°C
• PSA: 12.03000
• Density: 0.959g/cm³
• LogP: 1.22960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

7-Azabicyclo[2.2.1]heptane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Azabicyclo[2.2.1]heptane

There total 9 articles about 7-Azabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-azanorbornadiene (7092-27-5) → 7-aza-bicyclo[2.2.1]heptane (279-40-3)

Guidance literature:

With hydrogen; Lindlar's catalyst; In methanol;

Reference yield:

→ 7-aza-bicyclo[2.2.1]heptane (279-40-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

With sodium sulfate; In tetrahydrofuran; at 0 ℃; for 2h;

With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield:

trans-4-aminocyclohexyl p-toluenesulfonate hydrobromide → 7-aza-bicyclo[2.2.1]heptane (279-40-3)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 20h;

DOI:10.1021/ja036644z

upstream raw materials:

7-azanorbornadiene

trans-4-<(benzyloxycarbonyl)amino>cyclohexanol

trans-4-carbobenzoxyaminocyclohexyl p-toluenesulfonate

trans-4-hydroxycyclohexylamine

Downstream raw materials:

methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

7-(3-bromo-4-nitrophenyl)-7-azabicyclo[2.2.1]heptane

C₁₃H₁₅NO

C₃₂H₃₀N₂O₃

Refernces

• 1、 -. "Piperadinyl-substituted pyridylalkane, alkene and alkine carboxamides". . . Retrieved 2008/06/13.
• 2、 Altenbach, Hans-Josef,Constant, Dieter,Martin, Hans-Dieter,Mayer, Bernhard,Mueller, Monika,Vogel, Emanuel. "Syntheses and Photoelectron Spectra of 7-Azanorbornadiene and Related Compounds. An Analysis with Fragment Orbitals". . p. 791 - 801. Retrieved 2007/10/02.