2-Bromo-1-(4'-bromo-[1,1'-biphenyl]-4-yl)ethanone

Base Information

• Chemical Name: 2-Bromo-1-(4'-bromo-[1,1'-biphenyl]-4-yl)ethanone
• CAS No.: 94512-73-9
• Molecular Formula: C14H10 Br2 O
• Molecular Weight: 354.041
• DSSTox Substance ID: DTXSID00390918
• Wikidata: Q82188059
• Mol file: 94512-73-9.mol

Synonyms:94512-73-9;2-Bromo-1-(4'-bromo-[1,1'-biphenyl]-4-yl)ethanone;2-bromo-1-(4'-bromo-1,1'-biphenyl-4-yl)ethanone;2-bromo-1-[4-(4-bromophenyl)phenyl]ethanone;2-bromo-1-(4'-bromo-1,1'-biphenyl-4-yl) ethanone;2-bromo-1-(4'-bromo-[1,1'-biphenyl]-4-yl)ethan-1-one;2-bromo-1-(4'-bromo-biphenyl-4-yl)-ethanone;SCHEMBL973263;DTXSID00390918;MHUAWTIXPZEHRL-UHFFFAOYSA-N;STL431413;AKOS000116915;2-bromo-1-(4'-bromobiphenyl-4-yl)ethanone;CS-0268115;EN300-08174;2-bromo-1-[4-(4-bromophenyl)phenyl]ethan-1-one;Z104488504

Chemical Property of 2-Bromo-1-(4'-bromo-[1,1'-biphenyl]-4-yl)ethanone

Chemical Property:

• Boiling Point: 413.5°Cat760mmHg
• Flash Point: 118.6°C
• PSA: 17.07000
• Density: 1.642g/cm³
• LogP: 4.69370
• Storage Temp.: 2-8°C
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 353.90779
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

99%min ^*data from raw suppliers

2-bromo-1-(4'-bromo-1,1'-biphenyl-4-yl)ethanone 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)Br)C(=O)CBr

Technology Process of 2-Bromo-1-(4'-bromo-[1,1'-biphenyl]-4-yl)ethanone

There total 5 articles about 2-Bromo-1-(4'-bromo-[1,1'-biphenyl]-4-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-bromo-4'-acetylbiphenyl (5731-01-1) → 2-bromo-1-(4'-bromo<1,1'-biphenyl>-4-yl)ethanone (94512-73-9)

Guidance literature:

With pol(vinylphenyltrimethylammoniumtribromide) resin; In methanol; water; at 65 ℃; for 1h;

DOI:10.1080/00397911.2019.1631348

Reference yield: 70.0%

pyridine hydrobromide perbromide polymer resin + 4-bromo-4'-acetylbiphenyl (5731-01-1) → 2-bromo-1-(4'-bromo<1,1'-biphenyl>-4-yl)ethanone (94512-73-9)

Guidance literature:

In methanol; dichloromethane;

Reference yield: 66.0%

4-bromo-4'-acetylbiphenyl (5731-01-1) → C14H9Br3O (252741-01-8) + 2-bromo-1-(4'-bromo<1,1'-biphenyl>-4-yl)ethanone (94512-73-9)

Guidance literature:

With copper(ll) bromide; In chloroform; ethyl acetate; for 5h; Reflux;

DOI:10.1002/cmdc.201000120

upstream raw materials:

4-bromo-4'-acetylbiphenyl

4-bromo-1,1'-biphenyl

Downstream raw materials:

(2S,4S)-2-(2-(4'-bromobiphenyl-4-yl)-2-oxoethyl) 1-tert-butyl 4-methylpyrrolidine-1,2-dicarboxylate

2-[2-[4-(4-bromophenyl)phenyl]-2-oxo-ethyl]-1-tert-butyl-(2S,5S)-5-methylpyrrolidine-1,2-dicarboxylate

(2S,4S)-2-(2-(4'-bromobiphenyl-4-yl)-2-oxoethyl) 1-tert-butyl pyrrolidine-1,2-dicarboxylate

C₃₂H₂₄BrOP

Refernces

• 1、 Han, Bingbing,Zheng, Zubiao,Zheng, Dongcheng,Zhang, Lei,Cui, Peng,Shi, Jianjun,Li, Changjiang. "Application of poly(vinylphenyltrimethylammonium tribromide) resin as an efficient polymeric brominating agent in the α-bromination and α-bromoacetalization of acetophenones". supporting information. p. 2512 - 2520. Retrieved 2019/07/04.
• 2、 -. "HEPATITIS C VIRUS INHIBITORS". Page/Page column 98. . Retrieved 2012/01/05.