peimisine

Base Information

• Chemical Name: peimisine
• CAS No.: 19773-24-1
• Molecular Formula: C₂₇H₄₁NO₃
• Molecular Weight: 427.627
• Hs Code.: 29389090
• Mol file: 19773-24-1.mol

Synonyms:Veratraman-6(5H)-one, 17,23-epoxy-3-hydroxy-, (3beta)-;Peimisine;11-Deoxo-6-oxo-5a,6-dihydrojervine;

Chemical Property of peimisine

Chemical Property:

• Melting Point: 270℃
• Refractive Index: 1.577
• Boiling Point: 573 °C at 760 mmHg
• PKA: 14.89±0.70(Predicted)
• Flash Point: 300.3 °C
• PSA: 58.56000
• Density: 1.17 g/cm³
• LogP: 4.58960
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Peimisine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An alkaloid FR 5 from Fritillaria thunbergii. An angiotensin converting enzyme inhibitory steroidal alkaloid. Peimisine is a commonly used antitussive and expectorant herb in traditional Chinese medicine. An alkaloid FR 5 from Fritillaria thunbergii. An angiotensin converting enzyme inhibitory steroidal alkaloid. It is a commonly used antitussive and expectorant herb in traditional Chinese medicine.

Technology Process of peimisine

There total 1 articles about peimisine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

peimisine-3-O-β-D-glucopyranoside → D-glucose (50-99-7) + 11-deoxo-6-oxo-5α,6-dihydrojervine (19773-24-1)

Guidance literature:

With β-glucosidase; In dimethyl sulfoxide; at 40 ℃; for 10h;

DOI:10.1080/10286020.2011.619980

Reference yield:

11-deoxo-6-oxo-5α,6-dihydrojervine (19773-24-1) + benzoic acid (65-85-0,8013-63-6) → C34H45NO4

Guidance literature:

benzoic acid; With dmap; In dichloromethane;

11-deoxo-6-oxo-5α,6-dihydrojervine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1111/cbdd.14013

Reference yield:

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid (4530-18-1) + 11-deoxo-6-oxo-5α,6-dihydrojervine (19773-24-1) → C55H75N3O9 + C41H58N2O6

Guidance literature:

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid; With dmap; In dichloromethane;

11-deoxo-6-oxo-5α,6-dihydrojervine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1111/cbdd.14013

Refernces