(S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide

Base Information

• Chemical Name: (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide
• CAS No.: 119714-13-5
• Molecular Formula: C₁₀H₁₆N₂O₃S
• Molecular Weight: 244.315
• Mol file: 119714-13-5.mol

Synonyms:(S)-(+)-5-(2-aminopropyl)-2-methoxybenzene sulfonamide

Chemical Property of (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide

Chemical Property:

• Melting Point: 273-276 °C (decomp)
• Boiling Point: 445.5±55.0 °C(Predicted)
• PKA: 10.08±0.60(Predicted)
• Density: 1.247±0.06 g/cm3(Predicted)

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide

There total 3 articles about (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-hydroxyiminopropyl)-2-methoxybenzenesulfonamide (944395-49-7) → (S)-(+)-5-(2-aminopropyl)-2-methoxybenzene sulfonamide (119714-13-5) + 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide (112101-81-2)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 8h; under 2206.72 Torr;

Reference yield:

2-methoxy-5-(2-oxopropyl)benzenesulfonamide (116091-63-5) → (S)-(+)-5-(2-aminopropyl)-2-methoxybenzene sulfonamide (119714-13-5) + 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide (112101-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / methanol / 5 h / 20 °C

2: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 20 °C / 2206.72 Torr

With hydroxylamine hydrochloride; hydrogen; 5%-palladium/activated carbon; In methanol;

Reference yield:

(+/-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide (112244-38-9) → (S)-(+)-5-(2-aminopropyl)-2-methoxybenzene sulfonamide (119714-13-5) + 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide (112101-81-2)

Guidance literature:

With optical-resolution agent; diethylamine; In methanol; ethanol; at 40 ℃; Purification / work up; Optical-resolution column;

upstream raw materials:

(+/-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide

2-methoxy-5-(2-oxopropyl)benzenesulfonamide

5-(2-hydroxyiminopropyl)-2-methoxybenzenesulfonamide

Refernces

• 1、 -. "METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND". Page/Page column 8. . Retrieved 2008/06/13.