methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride

Base Information

• Chemical Name: methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride
• CAS No.: 1206824-67-0
• Molecular Formula: C₁₅H₂₂N₂O₂*ClH
• Molecular Weight: 298.813
• Mol file: 1206824-67-0.mol

Synonyms:methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride

Chemical Property of methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride

Chemical Property:

Purity/Quality:

98%+ ^*data from raw suppliers

Methyl(1-benzyl-4-methylpiperidin-3-yl)carbamatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride

There total 3 articles about methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl 4-methylpiperidin-3-ylcarbamate acetate (1206824-65-8) + benzaldehyde (100-52-7) → methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride (1206824-67-0)

Guidance literature:

methyl 4-methylpiperidin-3-ylcarbamate acetate; benzaldehyde; In acetic acid; toluene; at 20 ℃; for 2.5h;

With sodium tris(acetoxy)borohydride; In acetic acid; toluene; at 20 ℃; for 18h;

With hydrogenchloride; In water; toluene; at 80 ℃; for 2h;

Reference yield:

O-methyl-N-(4-methylpyridin-3-yl)carbamate (694495-63-1) → methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride (1206824-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen / 5% Rh/C / 72 h / 100 °C / 7757.43 Torr / Inert atmosphere

2.1: acetic acid / toluene / 2.5 h / 20 °C

2.2: 18 h / 20 °C / pH 7 - 7.5

2.3: 2 h / 80 °C

With hydrogen; acetic acid; 5% Rh/C; In toluene;

Reference yield:

3-amino-4-methylpyridine (3430-27-1) → methyl (1-benzyl-4-methylpiperidin-3-yl)carbamate hydrochloride (1206824-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 30 °C

1.2: 30 °C

2.1: hydrogen / 5% Rh/C / 72 h / 100 °C / 7757.43 Torr / Inert atmosphere

3.1: acetic acid / toluene / 2.5 h / 20 °C

3.2: 18 h / 20 °C / pH 7 - 7.5

3.3: 2 h / 80 °C

With potassium tert-butylate; hydrogen; acetic acid; 5% Rh/C; In tetrahydrofuran; toluene;

upstream raw materials:

methyl 4-methylpiperidin-3-ylcarbamate acetate

benzaldehyde

3-amino-4-methylpyridine

O-methyl-N-(4-methylpyridin-3-yl)carbamate

Downstream raw materials:

cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine bis(hydrochloride)

cis-1-benzyl-N,4-dimethylpiperidin-3-amine

4-((1-benzyl-4-methylpiperidin-3-yl)(methyl)amino)-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one

(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine

Refernces

• 1、 -. "THERAPEUTIC AGENTS". Page/Page column 28; 31-32. . Retrieved 2010/04/03.