methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate

Base Information

• Chemical Name: methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate
• CAS No.: 118794-92-6
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 118794-92-6.mol

Synonyms:methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate

Chemical Property of methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate

There total 5 articles about methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(4-methoxyphenyl)-2-phenyl-2H-tetrazole (20433-10-7) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate (118794-92-6)

Guidance literature:

In ethyl acetate; at 20 ℃; for 2h; UV-irradiation;

DOI:10.1021/ol7017328

Reference yield: 90.0%

methanol (67-56-1) + Methacryloyl chloride (920-46-7,26937-45-1) + 4-methoxybenzaldehydephenylhydrazone (622-73-1) → methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate (118794-92-6)

Guidance literature:

Methacryloyl chloride; With PEG 4000; Tri-n-octylamine; In dichloromethane; at 20 ℃; for 24h;

4-methoxybenzaldehydephenylhydrazone; With chloroamine-T; In dichloromethane; for 24h;

methanol; With sodium methylate; at 20 ℃; for 6h;

DOI:10.1055/s-2003-40863

Reference yield:

phenylhydrazine hydrochloride (59-88-1) → methyl 3-(4-methoxyphenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxylate (118794-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trioctylamine / methanol / 0.17 h / 20 °C

2.1: PEG 4000; trioctylamine / CH₂Cl₂ / 24 h / 20 °C

2.2: chloramine-T / CH₂Cl₂ / 24 h

2.3: 90 percent / MeONa / 6 h / 20 °C

With PEG 4000; Tri-n-octylamine; In methanol; dichloromethane;

DOI:10.1055/s-2003-40863

upstream raw materials:

5-(4-methoxyphenyl)-2-phenyl-2H-tetrazole

methacrylic acid methyl ester

C-(4-methoxyphenyl)-N-phenylnitrile imine

methanol

Refernces

• 1、 Wang, Yan-Guang,Zhang, Jian,Lin, Xu-Feng,Ding, Han-Feng. "Parallel synthesis of pyrazolines on soluble polymer support". . p. 1467 - 1468. Retrieved 2007/10/03.
• 2、 Lohse, V.,Leihkauf, P.,Csongar, Ch.,Tomaschewski, G.. "Photochemistry of Diarylsubstituted 2H-Tetrazoles. VI. Quantumyields of the Photolysis of Diarylsubstituted 2H-Tetrazoles". . p. 406 - 414. Retrieved 2007/10/02.