S-p-methylbenzyl chloro<2H₂>methyl sulfide

Base Information

• Chemical Name: S-p-methylbenzyl chloro<2H₂>methyl sulfide
• CAS No.: 73960-27-7
• Molecular Formula: C₉H₁₁ClS
• Molecular Weight: 188.689
• Mol file: 73960-27-7.mol

Synonyms:S-p-methylbenzyl chloro<2H₂>methyl sulfide

Chemical Property of S-p-methylbenzyl chloro<2H₂>methyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of S-p-methylbenzyl chloro<2H₂>methyl sulfide

There total 1 articles about S-p-methylbenzyl chloro<2H₂>methyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

paraformaldehyde-d2 (1664-98-8,43094-80-0) + 4-methylbenzylthiol (4498-99-1) → S-p-methylbenzyl chloro<2H2>methyl sulfide (73960-27-7)

Guidance literature:

With hydrogenchloride; calcium chloride; In benzene; for 24h; Ambient temperature;

DOI:10.1021/ja00528a004

Reference yield: 52.0%

S-p-methylbenzyl chloro<2H2>methyl sulfide (73960-27-7) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → diethyl 2-acetamido-2-S-p-methylbenzylthio<2H2>methylmalonate (73960-28-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 60h;

DOI:10.1021/ja00528a004

Reference yield:

S-p-methylbenzyl chloro<2H2>methyl sulfide (73960-27-7) → N-acetyl-S-p-methylbenzyl-DL-<β2,β3-2H2>cysteine (73960-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / sodium hydride / dimethylformamide / 60 h / 90 - 100 °C

2: 95 percent / conc. HCl / 6 h / Heating

3: 90 percent / Na₂CO₃ / H₂O / 0.33 h

With hydrogenchloride; sodium hydride; sodium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/ja00528a004

upstream raw materials:

paraformaldehyde-d2

4-methylbenzylthiol

Downstream raw materials:

diethyl 2-acetamido-2-S-p-methylbenzylthio<2H₂>methylmalonate

N-acetyl-S-p-methylbenzyl-DL-<β2,β3-2H₂>cysteine

N'-tert-butoxycarbonyl-S-p-methylbenzyl-L-<β2,β3-2H₂>cysteine

S-p-methylbenzyl-DL-<β2,β3-2H₂>cysteine

Refernces