6-AMINO-5-BROMO-1-METHYLURACIL MONOHYDRATE

Base Information

• Chemical Name: 6-AMINO-5-BROMO-1-METHYLURACIL MONOHYDRATE
• CAS No.: 14094-37-2
• Molecular Formula: C5H6BrN3O2
• Molecular Weight: 220.026
• Hs Code.: 2933599090
• Mol file: 14094-37-2.mol

Synonyms:Uracil,6-amino-5-bromo-1-methyl- (7CI,8CI);1-Methyl-5-bromo-6-aminouracil;5-Bromo-6-amino-1-methyluracil;6-Amino-5-bromo-1-methyl-1H-pyrimidine-2,4-dione;6-Amino-5-bromo-1-methyluracil;NSC 81011;

Chemical Property of 6-AMINO-5-BROMO-1-METHYLURACIL MONOHYDRATE

Chemical Property:

• Appearance/Colour: White solid
• Melting Point: >300 °C
• PSA: 80.88000
• Density: 1.868 g/cm³
• LogP: -0.00050
• Solubility.: DMSO, DMF

Purity/Quality:

98%min ^*data from raw suppliers

6-Amino-5-bromo-1-methyluracil ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-AMINO-5-BROMO-1-METHYLURACIL MONOHYDRATE

There total 3 articles about 6-AMINO-5-BROMO-1-METHYLURACIL MONOHYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

6-amino-1-methyluracil (2434-53-9) → 6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione (14094-37-2)

Guidance literature:

With bromine; sodium acetate; In acetic acid; at 20 - 125 ℃;

DOI:10.1002/jlcr.1154

Reference yield:

6-amino-1-methyluracil (2434-53-9) → 6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione (14094-37-2) + 5,5-dibromo-6-imino-1-methyl-dihydro-pyrimidine-2,4-dione

Guidance literature:

With water; bromine;

DOI:10.1039/jr9560000917

Reference yield:

→ 6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione (14094-37-2)

Guidance literature:

upstream raw materials:

6-amino-1-methyluracil

Downstream raw materials:

Linagliptin

C₁₆H₁₇ClN₄O₂S

Refernces

• 1、 Altman, Michael D.,Bogen, Stephane,Cai, Mingmei,Cammarano, Carolyn,Chen, Dapeng,Christopher, Matthew,Cryan, John,Daublain, Pierre,Dussault, Isabelle,Fradera, Xavier,Geda, Prasanthi,Goldenblatt, Peter,Hill, Armetta D.,Kemper, Raymond A.,Kutilek, Victoria,Li, Chaomin,Machacek, Michelle R.,Marshall, C. Gary,Martinez, Michelle,McCoy, Mark,Nair, Latha,Pan, Weidong,Reutershan, Michael H.,Scapin, Giovanna,Shizuka, Manami,Spatz, Marianne L.,Steinhuebel, Dietrich,Sun, Binyuan,Thompson, Christopher F.,Trotter, B. Wesley,Voss, Matthew E.,Wang, Xiao,Yang, Liping,Yeh, Tammie C.. "Discovery of MK-4688: An Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction". . p. 16213 - 16241. Retrieved 2021/11/16.
• 2、 Ma, Qi-Sheng,Yao, Yongfang,Zheng, Yi-Chao,Feng, Siqi,Chang, Junbiao,Yu, Bin,Liu, Hong-Min. "Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors". . p. 555 - 567. Retrieved 2018/11/26.