2-(4-fluorophenyl)-quinazoline

Base Information

• Chemical Name: 2-(4-fluorophenyl)-quinazoline
• CAS No.: 1208259-07-7
• Molecular Formula: C₁₄H₉FN₂
• Molecular Weight: 224.237
• Mol file: 1208259-07-7.mol

Synonyms:2-(4-fluorophenyl)-quinazoline

Chemical Property of 2-(4-fluorophenyl)-quinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-quinazoline

There total 25 articles about 2-(4-fluorophenyl)-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-fluorobenzaldehyde (459-57-4) + 2-amino-1-benzylamine (4403-69-4) → 2-(4-fluorophenyl)-quinazoline (1208259-07-7)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 0.7h; Green chemistry;

DOI:10.1016/j.tetlet.2017.04.036

Reference yield: 97.0%

2-Aminobenzyl alcohol (5344-90-1) + 4-fluorobenzaldehyde (459-57-4) → 2-(4-fluorophenyl)-quinazoline (1208259-07-7)

Guidance literature:

With [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cerium(III) nitrate hexahydrate; oxygen; ammonium chloride; copper(l) chloride; potassium hydroxide; In acetonitrile; at 30 - 80 ℃; for 48h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/jo401908g

Reference yield: 92.0%

4-fluorobenzylic alcohol (459-56-3) + 2-amino-1-benzylamine (4403-69-4) → 2-(4-fluorophenyl)-quinazoline (1208259-07-7)

Guidance literature:

4-fluorobenzylic alcohol; With oxygen; carbonic acid dimethyl ester; at 80 ℃; for 6h;

2-amino-1-benzylamine; at 80 ℃; for 18h; Catalytic behavior;

DOI:10.1016/j.mcat.2021.111499

upstream raw materials:

p-fluorobenzamide

2-bromobenzylamine

4-fluorobenzaldehyde

2-amino-1-benzylamine

Downstream raw materials:

(E)-2-(4-fluorophenyl)-4-styrylquinazoline

Refernces

• 1、 Yao, Nan,Bi, Xiuru,Zhang, Liping,Tao, Luyao,Zhao, Peiqing,Meng, Xu,Liu, Xiang. "Mixed crystalline phases and catalytic performance of OMS-2 based nanocomposites for one-pot synthesis of quinazolines with O2 as an oxidant". . . Retrieved 2021.
• 2、 Tiwari, Abhishek R.,Bhanage, Bhalchandra M.. "Synthesis of quinazolines from 2-aminobenzylamines with benzylamines and N-substituted benzylamines under transition metal-free conditions". . p. 10567 - 10571. Retrieved 2016.
• 3、 Kaur, Lovjot,Kaur, Harpreet,Kumar, Manoj,Bhalla, Vandana. "Type I ‘Lighted Metal-free’ Photosensitizing Assemblies of Phenazine for Aerobic Oxidative Transformations". supporting information. p. 4179 - 4186. Retrieved 2021/11/23.