[3]pyridyl-m-tolyl ketone

Base Information

• Chemical Name: [3]pyridyl-m-tolyl ketone
• CAS No.: 59190-58-8
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.236
• Mol file: 59190-58-8.mol

Synonyms:[3]pyridyl-m-tolyl ketone

Chemical Property of [3]pyridyl-m-tolyl ketone

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Pyridin-3-yl(m-tolyl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3]pyridyl-m-tolyl ketone

There total 1 articles about [3]pyridyl-m-tolyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-pyridyllithium (60573-68-4) + 3-Methylbenzonitrile (620-22-4) → [3]pyridyl-m-tolyl ketone (59190-58-8)

Guidance literature:

With diethyl ether; at -50 - -35 ℃; und Behandeln des Reaktionsgemisches mit wss. Salzsaeure;

DOI:10.1021/ja01145a508

Reference yield:

[3]pyridyl-m-tolyl ketone (59190-58-8) → C23H22N2O

Guidance literature:

Multi-step reaction with 2 steps

1: 110 °C / Inert atmosphere

2: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; sodium hydrogencarbonate / methanol; water / 65 °C / Inert atmosphere

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; sodium hydrogencarbonate; In methanol; water;

DOI:10.1002/anie.201703178

Reference yield:

[3]pyridyl-m-tolyl ketone (59190-58-8) → C23H22N2O + C23H22N2O

Guidance literature:

Multi-step reaction with 3 steps

1: 110 °C / Inert atmosphere

2: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; sodium hydrogencarbonate / methanol; water / 65 °C / Inert atmosphere

3: (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / tetrachloromethane / 20 °C / Schlenk technique; Inert atmosphere; Molecular sieve

With (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; sodium hydrogencarbonate; In methanol; tetrachloromethane; water; 3: |Pictet-Spengler Synthesis;

DOI:10.1002/anie.201703178

upstream raw materials:

3-pyridyllithium

3-Methylbenzonitrile