N-METHYLTHIABENDAZOLE

Base Information

• Chemical Name: N-METHYLTHIABENDAZOLE
• CAS No.: 32594-70-0
• Molecular Formula: C11H9 N3 S
• Molecular Weight: 215.279
• Hs Code.: 2934999090
• Mol file: 32594-70-0.mol

Synonyms:Benzimidazole,1-methyl-2-(4-thiazolyl)- (6CI,7CI,8CI); 1-Methylthiabendazole; G 491M;N-Methyl-2-(4'-thiazolyl)benzimidazole; N-Methylthiabendazole

Chemical Property of N-METHYLTHIABENDAZOLE

Chemical Property:

• Vapor Pressure: 2.92E-07mmHg at 25°C
• Boiling Point: 420°Cat760mmHg
• Flash Point: 207.8°C
• PSA: 58.95000
• Density: 1.36g/cm³
• LogP: 2.69680

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYLTHIABENDAZOLE

There total 5 articles about N-METHYLTHIABENDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

thiabendazole (148-79-8,98002-42-7) + methyl iodide (74-88-4) → 4-(1-methyl-1H-benzo[d]imidazol-2-yl)thiazole (32594-70-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2015.03.085

Reference yield: 90.0%

thiabendazole (148-79-8,98002-42-7) → 4-(1-methyl-1H-benzo[d]imidazol-2-yl)thiazole (32594-70-0)

Guidance literature:

With Amberlite IRA-400 (Cl^(1-)form) resin; In methanol;

DOI:10.1016/j.ejps.2003.09.001

Reference yield:

1,2-diamino-benzene (95-54-5) → 4-(1-methyl-1H-benzo[d]imidazol-2-yl)thiazole (32594-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium metabisulfite / N,N-dimethyl-formamide / 120 °C

2: sodium hydride / N,N-dimethyl-formamide / 20 °C

With sodium metabisulfite; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.03.085

upstream raw materials:

thiabendazole

methyl iodide

diazomethane

1,2-diamino-benzene

Refernces

• 1、 Tsuchiya,Tanaka,Fukuoka,Sato,Yamaha. "Metabolism of thiabendazole and teratogenic potential of its metabolites in pregnant mice". . p. 2985 - 2993. Retrieved 1987.
• 2、 Pan, Liangkun,Hang, Nan,Zhang, Chao,Chen, Yu,Li, Shuchun,Sun, Yang,Li, Zhongjun,Meng, Xiangbao. "Synthesis and biological evaluation of novel benzimidazole derivatives and analogs targeting the NLRP3 inflammasome". . . Retrieved 2017/03/09.