Technology Process of 5-[2-(benzyloxycarbonyl)amino-2-tert-butoxycarbonyl]ethyl-3-phenyl-3-vinyldihydrobenzo[b]furan-2-one
There total 7 articles about 5-[2-(benzyloxycarbonyl)amino-2-tert-butoxycarbonyl]ethyl-3-phenyl-3-vinyldihydrobenzo[b]furan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silver orthophosphate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
N,N-dimethyl acetamide;
at 100 ℃;
for 48h;
DOI:10.1039/b510653b
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
2: NaI; chloramine T / dimethylsulfoxide / 24 h
3: 74 percent / DCC / CH2Cl2 / 2 h / 0 °C
4: 63 percent / Ag3PO4; (S)-BINAP / Pd2(dba)3*CHCl3 / N,N-dimethyl-acetamide / 48 h / 100 °C
With
silver orthophosphate; chloroamine-T; sodium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); dicyclohexyl-carbodiimide; sodium iodide;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
diethyl ether; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide;
4: Heck reaction;
DOI:10.1039/b510653b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Bu3SnH / Pd(PPh3)4 / tetrahydrofuran / 20 °C
1.2: CuI / Pd(PPh3)4 / dimethylformamide / 20 °C
1.3: 1.63 g / KOH / ethanol / 24 h / Heating
2.1: 74 percent / DCC / CH2Cl2 / 2 h / 0 °C
3.1: 63 percent / Ag3PO4; (S)-BINAP / Pd2(dba)3*CHCl3 / N,N-dimethyl-acetamide / 48 h / 100 °C
With
silver orthophosphate; tri-n-butyl-tin hydride; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); dicyclohexyl-carbodiimide;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
1.2: Stille reaction / 3.1: Heck reaction;
DOI:10.1039/b510653b
