2-<2-(3-chlorophenyl)hydrazino>tropone

Base Information

• Chemical Name: 2-<2-(3-chlorophenyl)hydrazino>tropone
• CAS No.: 53526-92-4
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.696
• Mol file: 53526-92-4.mol

Synonyms:2-<2-(3-chlorophenyl)hydrazino>tropone

Chemical Property of 2-<2-(3-chlorophenyl)hydrazino>tropone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-(3-chlorophenyl)hydrazino>tropone

There total 3 articles about 2-<2-(3-chlorophenyl)hydrazino>tropone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(tosyloxy)tropone (38768-08-0) + 3-chlorophenyl hydrazine (14763-20-3) → 2-<2-(3-chlorophenyl)hydrazino>tropone (53526-92-4)

Guidance literature:

With triethylamine;

DOI:10.1246/cl.1986.1577

Reference yield: 2.0%

2-(tosyloxy)tropone (38768-08-0) + m-chlorophenylhydrazine hydrochloride (2312-23-4) → 2-<2-(3-chlorophenyl)hydrazino>tropone (53526-92-4) + 3-<2-(3-chlorophenyl)-2-methylhydrazino>tropone + 6,6'-bis<(3-chlorophenyl)hydrazono>-1,1'-bi(2,4-cycloheptadiene)-7,7'-dione

Guidance literature:

With triethylamine; In methanol; Heating;

DOI:10.1246/bcsj.61.2531

Reference yield:

2-hydroxy-2,4,6-cycloheptatrien-1-one (533-75-5) → 2-<2-(3-chlorophenyl)hydrazino>tropone (53526-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / pyridine / 20 °C

2: 80 percent / triethylamine / methanol / Heating

With pyridine; triethylamine; In methanol;

DOI:10.1246/bcsj.61.2531

upstream raw materials:

2-(tosyloxy)tropone

m-chlorophenylhydrazine hydrochloride

3-chlorophenyl hydrazine

2-hydroxy-2,4,6-cycloheptatrien-1-one

Downstream raw materials:

3-chloro-6H-cycloheptindol-6-one

2-amino-5-(4-amino-2-chlorophenyl)tropone

5-(3-Chloro-phenylamino)-2-(3-chloro-phenylazo)-cyclohepta-2,4,6-trienone

3,3'-Bis-[(3-chloro-phenyl)-hydrazono]-bicycloheptyl-4,6,4',6'-tetraene-2,2'-dione

Refernces

• 1、 Nozoe, Tetsuo,Takase, Kahei,Saito, Hiroaki,Yamamoto, Hiroshi,Imafuku, Kimiaki. "A Convenient Synthesis of 5-Aryltropolones via Novel Benzidine Type Rearrangement of 2-(2-Arylhydrazino)tropones". . p. 1577 - 1580. Retrieved 2007/10/02.