Dehydrocorydaline

Base Information

• Chemical Name: Dehydrocorydaline
• CAS No.: 30045-16-0
• Molecular Formula: C₂₂H₂₄NO₄
• Molecular Weight: 366.437
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30904183
• Nikkaji Number: J19.822F
• Wikidata: Q27155279
• Metabolomics Workbench ID: 125407
• ChEMBL ID: CHEMBL1917176
• Mol file: 30045-16-0.mol

Synonyms:dehydrocorydalin;dehydrocorydalin chloride;dehydrocorydaline

Chemical Property of Dehydrocorydaline

Chemical Property:

• Appearance/Colour: Orange Powder
• Melting Point: 170-173 oC
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 40.80000
• Density: g/cm³
• LogP: 3.69320
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 366.17053325
• Heavy Atom Count: 27
• Complexity: 503

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dehydrocorydaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CC(=C(C2=C[N+]3=C1C4=CC(=C(C=C4CC3)OC)OC)OC)OC

Technology Process of Dehydrocorydaline

There total 15 articles about Dehydrocorydaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-(+-)-5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine (6018-35-5) → dehydrocorydaline (30045-16-0)

Guidance literature:

With iodine; potassium acetate; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201601245

Reference yield: 89.0%

2-(2-(7,8-dimethoxy-4-methylisoquinolin-3-yl)4,5-dimethoxyphentl)ethan-1-ol → dehydrocorydaline (30045-16-0)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield: 67.0%

C22H25NO4 → dehydrocorydaline (30045-16-0)

Guidance literature:

With rhodium(III) chloride trihydrate; oxygen; In ethanol; at 80 ℃; for 8h;

DOI:10.1002/chem.201601245

upstream raw materials:

mercury(II) diacetate

acetic acid

corydaline

water

Downstream raw materials:

mesocorydaline

Refernces

• 1、 Zhou, Shiqiang,Tong, Rongbiao. "A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps". . p. 7084 - 7089. Retrieved 2016/05/19.