Ceftazidine

Base Information

• Chemical Name: Ceftazidine
• CAS No.: 78439-06-2
• Molecular Formula: C₂₂H₂₂N₆O₇S₂*5H₂O
• Molecular Weight: 636.661
• Hs Code.: 29419000
• Mol file: 78439-06-2.mol

Synonyms:Ceftazidine

Chemical Property of Ceftazidine

Chemical Property:

• Appearance/Colour: white solid
• Melting Point: >150oC(dec.)
• PKA: pKa 1.8 (Uncertain)
• PSA: 244.76000
• LogP: -0.38920
• Storage Temp.: 2-8°C
• Solubility.: Sparingly soluble in aqueous solution
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 9
• Exact Mass: 564.10970409
• Heavy Atom Count: 38
• Complexity: 1030

Purity/Quality:

95%-102% ^*data from raw suppliers

CeftazidimePentahydrate(Contain1equivalentofNa2CO3asstabilizer) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45-37-24

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)O.[OH-]
• Isomeric SMILES: CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)O.[OH-]
• Description: Ceftazidime is the latest third generation cephalosporin to reach the market. It has one of the broadest spectrums of the cephalosporins, similar in many regards to that of cefotaxime. It is particularly active against Pseudomonas aeruginosa, being perhaps 4-5 times more potent in vitro than moxalactam and cefotaxime.
• Uses: Third generation cephalosporin antibiotic. Antibacterial. Ceftazidime pentahydrate is an antibacterial agent. It is used especially for Pseudomonas and other gram-negative infections in debilitated patients. It is used in the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis).
• Clinical Use: It is used, often combined with an aminoglycoside, to treat a wide range of severe urinary, respiratory and wound infections, mostly due to enterobacteria or Ps. aeruginosa. Reference is made to its use in pneumonia, septicemia, meningitis (especially if caused by Ps. aeruginosa), peritonitis, osteomyelitis, neonatal sepsis, burns and melioidosis. Concern has been expressed at the relative frequency with which failure is associated with superinfection or the emergence of resistance.

Technology Process of Ceftazidine

There total 2 articles about Ceftazidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ceftazidime pentahydrate (120618-65-7,78439-06-2)

Guidance literature:

Reference yield:

→ (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetamido]-3-(pyridinium-1-ylmethyl)ceph-3-em-4-carboxylate Hydrate (120618-65-7,78439-06-2)

Guidance literature:

Refernces

• 1、 -. "Process for the production of cephalosporin derivatives". . . Retrieved 2008/06/13.
• 2、 -. "(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetamido]-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylate and salts thereof". . . Retrieved 2008/06/13.