3-(3-fluorophenyl)propiolic acid

Base Information

• Chemical Name: 3-(3-fluorophenyl)propiolic acid
• CAS No.: 705-83-9
• Molecular Formula: C₉H₅FO₂
• Molecular Weight: 164.136
• Mol file: 705-83-9.mol

Synonyms:3-(m-fluorophenyl)-propiolic acid

Chemical Property of 3-(3-fluorophenyl)propiolic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

3-(3-fluorophenyl)prop-2-ynoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-fluorophenyl)propiolic acid

There total 5 articles about 3-(3-fluorophenyl)propiolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + 1-ethynyl-3-fluoro-benzene (2561-17-3) → 3-(m-fluorophenyl)-propiolic acid (705-83-9)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 60 ℃; for 24h; Sealed tube; Inert atmosphere;

Reference yield: 84.0%

→ 3-(m-fluorophenyl)-propiolic acid (705-83-9)

Guidance literature:

With diethoxymethylane; potassium tert-butylate; at 40 ℃; for 2h; Glovebox; Schlenk technique; Green chemistry;

Reference yield:

methyl 3-(3-fluorophenyl)prop-2-ynoate (221148-38-5) → 3-(m-fluorophenyl)-propiolic acid (705-83-9)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2020.152378

upstream raw materials:

carbon dioxide

1-ethynyl-3-fluoro-benzene

1-Fluoro-3-iodobenzene

Propiolic acid

Refernces

• 1、 Shi, Jun-Bin,Bu, Qingqing,Liu, Bin-Yuan,Dai, Bin,Liu, Ning. "Organocatalytic Strategy for the Fixation of CO2via Carboxylation of Terminal Alkynes". . p. 1850 - 1860. Retrieved 2021/01/14.
• 2、 Luo, Jun,Wan, Zi-Juan,Yuan, Xiao-Feng. "Visible light induced 3-position-selective addition of arylpropiolic acids with ethersviaC(sp3)-H functionalization". supporting information. p. 3258 - 3262. Retrieved 2020/05/14.