2,2',2'',2'''-(Ethylenebisnitrilo)tetrakis(acetic acid ethyl) ester

Base Information

• Chemical Name: 2,2',2'',2'''-(Ethylenebisnitrilo)tetrakis(acetic acid ethyl) ester
• CAS No.: 3626-00-4
• Molecular Formula: C18H32N2O8
• Molecular Weight: 404.46
• Hs Code.: 2922499990
• Mol file: 3626-00-4.mol

Synonyms:ethyl 2-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate;

Chemical Property of 2,2',2'',2'''-(Ethylenebisnitrilo)tetrakis(acetic acid ethyl) ester

Chemical Property:

• Melting Point: 30-32 °C
• Boiling Point: 195-196 °C(Press: 3 Torr)
• PKA: 3.81±0.50(Predicted)
• Flash Point: 234.4oC
• PSA: 111.68000
• Density: 1.142±0.06 g/cm3(Predicted)
• LogP: -0.15720

Purity/Quality:

99% ^*data from raw suppliers

Ethylenediamine-N,N,N’,N’-tetraaceticAcidTetraethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethylenediamine-N,N,N’,N’-tetraacetic Acid (E917745) derivative. Chelating agent.

Technology Process of 2,2',2'',2'''-(Ethylenebisnitrilo)tetrakis(acetic acid ethyl) ester

There total 4 articles about 2,2',2'',2'''-(Ethylenebisnitrilo)tetrakis(acetic acid ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethylenediaminetetraacetic acid (60-00-4,94108-75-5) + ethanol (64-17-5) → ethylenediaminetetraacetic acid tetraethyl ester (3626-00-4)

Guidance literature:

ethylenediaminetetraacetic acid; ethanol; With sulfuric acid; at 90 ℃; for 17h; Inert atmosphere;

With sodium hydrogencarbonate; In water; pH=9;

Reference yield:

ethylenediaminetetraacetic acid (60-00-4,94108-75-5) + dichloromethane (75-09-2) → ethylenediaminetetraacetic acid tetraethyl ester (3626-00-4)

Guidance literature:

With sulfuric acid; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) EtOH, reflux, 24 h, 2.) EtOH, H₂O;

DOI:10.1016/0040-4020(84)85050-4

Reference yield:

chloroacetic acid ethyl ester (105-39-5) + ethylenediamine (107-15-3,85404-18-8) → ethylenediaminetetraacetic acid tetraethyl ester (3626-00-4)

Guidance literature:

With potassium carbonate;

upstream raw materials:

chloroacetic acid ethyl ester

ethylenediamine

ethylenediaminetetraacetic acid

dichloromethane

Downstream raw materials:

{[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetic acid

Refernces

• 1、 Wathier, Michel,Grinstaff, Mark W.. "Synthesis and properties of supramolecular ionic networks". . p. 9648 - 9649. Retrieved 2008.
• 2、 -. "NOVEL CHELATOR AND USE THEREOF". Page/Page column 15. . Retrieved 2011/12/14.