Propiverine hydrochloride

Base Information

• Chemical Name: Propiverine hydrochloride
• CAS No.: 54556-98-8
• Molecular Formula: C23H29NO3^.HCl
• Molecular Weight: 403.949
• Hs Code.: 2933399090
• European Community (EC) Number: 641-384-5
• NSC Number: 172140
• UNII: DC4GZD10H3
• DSSTox Substance ID: DTXSID1046847
• Wikidata: Q27276325
• ChEMBL ID: CHEMBL2359059
• Mol file: 54556-98-8.mol

Synonyms:alpha-diphenyl alpha-n-propoxyacetic acid-4(1-methylpiperidyl)ester;Detrunorm;Mictonetten;Mictonorm;propiverin;propiverine;propiverine hydrochloride

Chemical Property of Propiverine hydrochloride

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 3.61E-10mmHg at 25°C
• Melting Point: 224-226 °C
• Boiling Point: 484.2 °C at 760 mmHg
• Flash Point: 246.6 °C
• PSA: 38.77000
• LogP: 4.73410
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: soluble5mg/mL, clear (warmed)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 403.1914215
• Heavy Atom Count: 28
• Complexity: 429

Purity/Quality:

99% ^*data from raw suppliers

Propiverine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C.Cl
• Recent ClinicalTrials: Effect of Interferential Electrical Stimulation on Pain Perception and Disability Level on Interstitial Cystitis
• Recent EU Clinical Trials: Efficacy of propiverine hydrochloride extended release (ER) 45 mg in patients with neurogenic detrusor overactivity – an active-controlled single center crossover trial
• Recent NIPH Clinical Trials: Efficacy of propiverine hydrochloride for urinary incontinence afterlaparoscopic radical prostatectomy
• Description: Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.
• Uses: Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.
• Clinical Use: Treatment of urinary frequency, urgency and incontinence Neurogenic bladder instability
• Drug interactions: Potentially hazardous interactions with other drugs Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Technology Process of Propiverine hydrochloride

There total 2 articles about Propiverine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propiverine (60569-19-9) → propiverine hydrochloride (54556-98-8)

Guidance literature:

With hydrogenchloride; In water; acetone; for 1h;

Reference yield:

N-methyl-4-hydroxypiperidine (106-52-5) + diphenyl-propoxy-acetic acid propyl ester (94686-44-9) → propiverine hydrochloride (54556-98-8)

Guidance literature:

N-methyl-4-hydroxypiperidine; diphenyl-propoxy-acetic acid propyl ester; With potassium tert-butylate; tetrabutyl-ammonium chloride; at 20 ℃; for 72h; Inert atmosphere;

With ammonium chloride;

With hydrogenchloride; In water; acetone; Product distribution / selectivity;

Reference yield: 48.0%

propiverine hydrochloride (54556-98-8) + methyl iodide (74-88-4) → 1,1-dimethyl-4-[(2,2-diphenyl-2-n-propoxy)acetoxy]piperidinium iodide (1558012-71-7)

Guidance literature:

propiverine hydrochloride; With sodium carbonate; In water;

methyl iodide; In ethanol; at 0 - 20 ℃; for 18h;

upstream raw materials:

N-methyl-4-hydroxypiperidine

diphenyl-propoxy-acetic acid propyl ester

propiverine

Downstream raw materials:

benzophenone

N-methyl-4-piperidyl benzilate

2,2-diphenyl-2-propoxyethanoic acid

Benzilic acid

Refernces

• 1、 -. "SYNTHESIS OF PROPIVERINE HYDROCHLORIDE". Page/Page column 6-7. . Retrieved 2011/10/10.