R-138727

Base Information

• Chemical Name: R-138727
• CAS No.: 204204-98-8
• Molecular Formula: C₁₈H₂₀FNO₃S
• Molecular Weight: 349.426
• Mol file: 204204-98-8.mol

Synonyms:R-138727

Chemical Property of R-138727

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R-138727

There total 9 articles about R-138727 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.12%

C19H22FNO3S → R-138727 (204204-98-8,204204-73-9)

Guidance literature:

With sodium hydroxide;

Reference yield:

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine → R-138727 (204204-98-8,204204-73-9)

Guidance literature:

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; With calcium chloride; cytochrome P₄₅₀; pH=7.4; aq. phosphate buffer;

With GLUTATHIONE; at 37 ℃; for 0.5h; pH=7.4; aq. phosphate buffer;

DOI:10.1021/tx3000279

Reference yield:

C6H12BrNS → R-138727 (204204-98-8,204204-73-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / diethyl ether / 24 °C

2: potassium phosphate; iodine / 7 h / 80 °C

3: potassium hydroxide / ethanol / 9.5 h

4: sodium hydroxide

With potassium phosphate; iodine; potassium hydroxide; sodium hydroxide; In diethyl ether; ethanol;

upstream raw materials:

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

GLUTATHIONE

R-133490

Downstream raw materials:

C₂₇H₂₈FNO₅S

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Refernces

• 1、 Dansette, Patrick M.,Levent, Dan,Hessani, Assia,Mansuy, Daniel. "Bioactivation of Clopidogrel and Prasugrel: Factors Determining the Stereochemistry of the Thiol Metabolite Double Bond". . p. 1338 - 1345. Retrieved 2015/06/25.
• 2、 Hagihara, Katsunobu,Kazui, Miho,Kurihara, Atsushi,Iwabuchi, Haruo,Ishikawa, Minoru,Kobayashi, Hiroyuki,Tanaka, Naoki,Okazaki, Osamu,Farid, Nagy A.,Ikeda, Toshihiko. "Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite". . p. 898 - 904. Retrieved 2011/03/18.