S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate

Base Information

• Chemical Name: S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate
• CAS No.: 213468-59-8
• Molecular Formula: C₁₁H₁₂O₂S₂
• Molecular Weight: 240.347
• Mol file: 213468-59-8.mol

Synonyms:S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate

Chemical Property of S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate

There total 2 articles about S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(4-methoxyphenyl)-3,3-bis(methylsulfanyl)propenone (33868-76-7) → S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate (213468-59-8)

Guidance literature:

With boron trifluoride diethyl etherate; hydrogen sulfide; In 1,4-dioxane; for 3h; Heating;

DOI:10.1080/00397919908086034

Reference yield: 73.0%

(S,S)-dimethyl trithiocarbonate (2314-48-9) + 1-(4-methoxyphenyl)ethanone (100-06-1) → S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate (213468-59-8)

Guidance literature:

With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo101572c

Reference yield: 98.0%

S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate (213468-59-8) → 4-methoxybenzoic acid (100-09-4)

Guidance literature:

With sodium hydroxide; In water; at 100 ℃; for 10h; Reagent/catalyst; chemoselective reaction; Reflux;

DOI:10.1016/j.tetlet.2017.05.064

upstream raw materials:

1-(4-methoxyphenyl)-3,3-bis(methylsulfanyl)propenone

(S,S)-dimethyl trithiocarbonate

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

2-(Bis-methylsulfanyl-methylene)-1-(4-methoxy-phenyl)-4-methyl-pent-4-en-1-one

ethyl 2-{[3-(4-methoxyphenyl)-3-oxopropanthioyl]amino}acetate

5-(4'-methoxyphenyl)-3-(methylthio)-1-phenyl-1H-pyrazole

ethyl 2-{[(E)-1-(ethylsulfanyl)-3-(4-methoxyphenyl)-3-oxo-1-propenyl]amino}acetate

Refernces

• 1、 Srivastava, Abhijeet,Shukla, Gaurav,Yadav, Dhananjay,Singh, Maya Shankar. "Access to Fully Substituted Thiazoles and 2,3-Dihydrothiazoles via Copper-Catalyzed [4 + 1] Heterocyclization of α-(N-Hydroxy/aryl)imino-β-oxodithioesters with α-Diazocarbonyls". supporting information. p. 10846 - 10854. Retrieved 2017/10/27.
• 2、 Matloubi Moghaddam, Firouz,Khodabakhshi, Mohammad Reza,Latifkar, Arash. "A one-pot multicomponent synthesis of polysubstituted thiophenes via the reactions of an isocyanide, α-haloketones, and β-ketodithioesters in water". . p. 1251 - 1254. Retrieved 2014/02/14.