TETRAGASTRIN

Base Information

• Chemical Name: TETRAGASTRIN
• CAS No.: 1947-37-1
• Molecular Formula: C29H36 N6 O6 S
• Molecular Weight: 596.707
• Mol file: 1947-37-1.mol

Synonyms:Alaninamide,L-tryptophyl-L-methionyl-L-aspartylphenyl- (7CI); Alaninamide,L-tryptophyl-L-methionyl-L-aspartylphenyl-, L- (8CI); L-Phenylalaninamide,L-tryptophyl-L-methionyl-L-a-aspartyl-; 18: PN: US20090075314 SEQID: 15 claimed protein; 4: PN:DE10255132 PAGE: 3/12 unclaimed sequence; 7: PN: WO2004045640 SEQID: 7 claimedprotein; Cholecystokinin 30-33; Cholecystokinin C-terminal tetrapeptide;Cholecystokinin(36-39); Tetragastrin

Chemical Property of TETRAGASTRIN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 185-195 °C
• Boiling Point: 1159.2°Cat760mmHg
• PKA: 4.19±0.10(Predicted)
• Flash Point: 654.8°C
• PSA: 247.11000
• Density: 1.341g/cm³
• LogP: 4.67950
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cholecystokinin Fragment 30-33 Amide ≥95% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Moderately toxic by ingestion.
• Hazard Codes: Moderately toxic by ingestion.

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.

Technology Process of TETRAGASTRIN

There total 15 articles about TETRAGASTRIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

L-Phenylalanine amide (5241-58-7) + H-Trp-Met-Asp-OH (97586-87-3) → cholecystokinin-4 (1947-37-1)

Guidance literature:

With thermolysin; In methanol; water; for 3h; Ambient temperature; pH 6.5;

DOI:10.1248/cpb.36.4345

Reference yield: 14.0%

Boc-Trp(Mts)-Met-Asp(OMen)-Phe-NH2 (110592-11-5) → cholecystokinin-4 (1947-37-1) + H-Trp-Met-Asc-Phe-NH2 (110575-53-6,111004-09-2) + H-Trp-Met-Asp(OMen)-Phe-NH2 (110575-54-7)

Guidance literature:

With trifluorormethanesulfonic acid; methyl-phenyl-thioether; diphenyl sulfide; In trifluoroacetic acid; for 2h;

Reference yield:

C29H35N5O7S (35144-91-3) → cholecystokinin-4 (1947-37-1)

Guidance literature:

With Bacillus licheniformis serine endoprotease; ammonia; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol; at 50 ℃; for 16h; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.tetlet.2012.05.039

upstream raw materials:

L-Phenylalanine amide

H-Trp-Met-Asp-OH

tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-pentafluorophenyl L-aspartate

N-α-fluorenylmethoxycarbonyl-L-tryptophan pentafluorophenyl ester

Downstream raw materials:

Trp-Met

H-Trp-Met-Asp-OH

1-chloromethyl-5-hydroxy-3-(5,6,7-trimethoxyindole-2-carbonyl)-2,3-dihydro-1H-benz[e]indole-7-carboxylic acid [β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanineamidyl] amide

Refernces

• 1、 Sakina,Kawazura,Morihara,Yajima. "Thermolysin-catalyzed synthesis of peptide amides". . p. 4345 - 4354. Retrieved 2007/10/02.
• 2、 Funakoshi, Susumu,Murayama, Eigoro,Guo, Lili,Fujii, Nobutaka,Yajima, Haruaki. "A Modified Benzhydrylamine as a Handle Reagent for the Solid Phase Synthesis of Peptide Amides Based on the Fluorenylmethoxycarbonyl Method". . p. 382 - 384. Retrieved 2007/10/02.