L-Dopa ethyl ester hydrochloride

Base Information

• Chemical Name: L-Dopa ethyl ester hydrochloride
• CAS No.: 23234-41-5
• Molecular Formula: C₁₁H₁₅NO₄*ClH
• Molecular Weight: 261.705
• Mol file: 23234-41-5.mol

Synonyms:L-Dopa ethyl ester hydrochloride

Chemical Property of L-Dopa ethyl ester hydrochloride

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Dopa ethyl ester hydrochloride

There total 2 articles about L-Dopa ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 3,4-dihydroxy-L-phenylalanine (59-92-7,90638-38-3) → 2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid ethyl ester; hydrochloride (23234-41-5,39740-30-2,92147-38-1)

Guidance literature:

With thionyl chloride; for 48h; Ambient temperature;

DOI:10.1021/jo00301a008

Reference yield:

dopa (63-84-3,90638-38-3) + ethanol (64-17-5) → L-Dopa ethyl ester hydrochloride (23234-41-5)

Guidance literature:

With thionyl chloride; for 48h; Ambient temperature;

DOI:10.1021/jo00301a008

Reference yield:

L-Dopa ethyl ester hydrochloride (23234-41-5) → alpha-methyldopa (55-40-3,555-29-3,88620-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) K₂CO₃ / 2.) Acetone

2: 1.) solid KOH 2.) 1N HCl / 1.) tetrabutylammonium iodide / 1.) acetonitrile, 0 to 15 deg C 2.) ether, 0 deg C_.

3: 1.) hydrogen 2.) 6N HCl / 1.) 10 percent Pd/C / 1.) ethanol

With hydrogenchloride; potassium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; tetra-(n-butyl)ammonium iodide;

DOI:10.1016/S0040-4039(00)88719-5

upstream raw materials:

dopa

ethanol

3,4-dihydroxy-L-phenylalanine

Downstream raw materials:

3-(3,4-Bis-benzyloxy-phenyl)-2-{[1-(2,4,6-trimethyl-phenyl)-meth-(Z)-ylidene]-amino}-propionic acid ethyl ester

1-(4-Chloro-phenyl)-6,7-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ethyl ester

3-(3,4-Bis-benzyloxy-phenyl)-2-(2,5-dioxo-pyrrolidin-1-yl)-propionic acid ethyl ester

N-[2-(3,4-Bis-benzyloxy-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

Refernces