Aqupla

Base Information

• Chemical Name: Aqupla
• CAS No.: 95734-82-0
• Molecular Formula: C₂H₈N₂O₃Pt
• Molecular Weight: 303.177
• NCI Thesaurus Code: C61099
• Wikipedia: Nedaplatin
• Mol file: 95734-82-0.mol

Synonyms:(glycolato-O,O')diammineplatinum II;254-S;CGDP-II;cis-diammine(glycolato)platinum II;nedaplatin;NSC 375101D;NSC-375101D

Chemical Property of Aqupla

Chemical Property:

• Appearance/Colour: Straw yellow powder
• Boiling Point: 265.6oC at 760 mmHg
• Flash Point: 128.7oC
• PSA: 42.01000
• LogP: 0.12010
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 305.033937
• Heavy Atom Count: 8
• Complexity: 44.1

Purity/Quality:

99% ^*data from raw suppliers

Nedaplatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)O)O.N.N.[Pt]
• Recent ClinicalTrials: Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell Carcinoma
• Recent NIPH Clinical Trials: A phase II study of biweekly Docetaxel + Nedaplatin in advanced esophageal cancer in patients previously treated with FP and anti-PD-1 antibodies
• Description: Nedaplatin, a novel second generation platinum complex, was marketed in Japan for the treatment of a variety of cancers including: head and neck, small-cell and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder, and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more active than cisplatin against several solid tumors while sharing less nephro- and gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by nedaplatin allows its use in patients with deteriorated renal function.
• Uses: Nedaplatin is a platinum complex that has potent antineoplatic activity.

Technology Process of Aqupla

There total 4 articles about Aqupla which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

cis-diaminediiodoplatinum(II) + 2K(1+)*Cl4Pt + hydroxyacetic acid silver salt (13126-71-1) → nedaplatin (95734-82-0)

Guidance literature:

cis-diaminediiodoplatinum(II); 2K⁽¹⁺⁾*Cl₄Pt; hydroxyacetic acid silver salt; In water; at 20 ℃; Darkness;

With Amberlite-HCl; pH=9 - 10; Darkness;

DOI:10.1021/jm3016427

Reference yield: 43.0%

glycolic Acid (79-14-1) + cis-diaminedinitroplatinum(II) (41575-87-5,14286-03-4,74006-35-2) → nedaplatin (95734-82-0)

Guidance literature:

In water; aq. soln. of Pt-complex was passed through column with anion exchange resin (OH(1-) type); addn. of glycolic acid to eluate; room temp., 24 h; heating at 55°C for 6 h; crystn. on concn.; filtration; recrystn. (water); elem. anal.;

DOI:10.1246/cl.1986.429

Reference yield: 28.0%

cis-diaminedinitroplatinum(II) (41575-87-5,14286-03-4,74006-35-2) + sodium glycolate (25289-18-3,105938-46-3,2836-32-0) → nedaplatin (95734-82-0)

Guidance literature:

With sodium hydroxide; In water; addn. of sodium glycolate to Pt-complex in H2O; pH was adjusted to 7 with NaOH; stirring for 3 h; concn. at 50-60°C under reduced pressure; filtration; washing (chilled water); drying (vac.); elem. anal.;

DOI:10.1246/cl.1986.429

upstream raw materials:

cis-diaminedinitroplatinum(II)

sodium glycolate

glycolic Acid

cisplatin

Refernces

• 1、 Totani, Tetsushi,Aono, Katsutoshi,Komura, Michihiro,Adachi, Yasuko. "SYNTHESIS OF (GLYCOLATO-O,O')DIAMMINEPLATINUM(II) AND ITS RELATED COMPLEXES". . p. 429 - 432. Retrieved 2007/10/02.