N-(2-Hydroxyethyl)propionamide

Base Information

• Chemical Name: N-(2-Hydroxyethyl)propionamide
• CAS No.: 18266-55-2
• Molecular Formula: C5H11 N O2
• Molecular Weight: 117.148
• Hs Code.: 2924199090
• European Community (EC) Number: 242-145-4
• NSC Number: 6001
• UNII: CM7KQV2OEE
• DSSTox Substance ID: DTXSID7066350
• Nikkaji Number: J26.763E
• Wikidata: Q81992949
• Mol file: 18266-55-2.mol

Synonyms:N-(2-Hydroxyethyl)propionamide;18266-55-2;N-(2-Hydroxyethyl)propanamide;Propanamide, N-(2-hydroxyethyl)-;N-Propionylethanolamine;Propionamide, N-(2-hydroxyethyl)-;Propionylaminoethanol;CM7KQV2OEE;N-(.beta.-Hydroxyethyl)propionamide;beta-Hydroxyethylpropionamide;.beta.-Hydroxyethylpropionamide;N-(2-hydroxylethyl)propionamide;N-(beta-Hydroxyethyl)propionamide;NSC 6001;NSC-6001;EINECS 242-145-4;AI3-15237;NSC6001;UNII-CM7KQV2OEE;SCHEMBL498932;DTXSID7066350;n-(2-hydroxyethyl) propionamide;N-(2-Hydroxyethyl)propanamide #;MFCD00059600;AKOS008929790;BS-21808;N-(2-Hydroxyethyl)propanamide, AldrichCPR;CS-0449194;FT-0738020;H0549;D90897;N-(2-HYDROXYETHYL)PROPIONIC ACID AMIDE;1-(4-fluorophenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylicacid

Chemical Property of N-(2-Hydroxyethyl)propionamide

Chemical Property:

• Vapor Pressure: 3.51E-05mmHg at 25°C
• Refractive Index: 1.4690-1.4720
• Boiling Point: 316.2°Cat760mmHg
• Flash Point: 145.1°C
• PSA: 49.33000
• Density: 1.023g/cm³
• LogP: -0.10420
• Water Solubility.: Soluble in water
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 72.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2-Hydroxyethyl)propionamide >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NCCO

Technology Process of N-(2-Hydroxyethyl)propionamide

There total 8 articles about N-(2-Hydroxyethyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetaldehyde (75-07-0,9002-91-9) + Propionamid (79-05-0) → N-(2-hydroxyethyl)propionamide (18266-55-2)

Guidance literature:

With potassium carbonate; diphenylamine; at 10 ℃; for 3h; Inert atmosphere;

Reference yield:

propionic acid anhydride (123-62-6) → N-(2-hydroxyethyl)propionamide (18266-55-2)

Guidance literature:

propionic acid anhydride; NH₂(CH₂)2-O-2-chlorotrityl resin; With HATU;

With chlorotriisopropylsilane; trifluoroacetic acid; at 20 ℃; for 2h;

With piperidine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.12.052

Reference yield:

ethanolamine (141-43-5) + propionic acid (802294-64-0,79-09-4) → N-(2-hydroxyethyl)propionamide (18266-55-2)

Guidance literature:

at 160 - 200 ℃; unter Abdestillieren des gebildeten Wassers;

upstream raw materials:

ethanolamine

propionic acid

Ethyl propionate

propionic acid anhydride

Downstream raw materials:

8-methyl-5-phenyl-2,3-dihydro-thiazolo[3,2-c]pyrimidin-7-one

6-benzoyl-8-methyl-2,3-dihydro-thiazolo[3,2-c]pyrimidine-5,7-dione

N-<2-(methylphenylamino)-ethyl>-propanamide

N-phenyl-N'-propionylethylenediamine

Refernces

• 1、 Rajan. "Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation". . p. 287 - 291. Retrieved 2015/01/30.
• 2、 Zhou, Aihua,Pittman Jr., Charles U.. "Generation of cyclic ketene-N,X-acetals (X = O, S) from 2-alkyl-1,3-oxazolines and 2-alkyl-1,3-thiazolines. Reactions with acid chlorides, 1,3-diacid chlorides and N-(chlorocarbonyl) isocyanate". . p. 37 - 48. Retrieved 2007/10/03.