4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol

Base Information

• Chemical Name: 4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol
• CAS No.: 301669-90-9
• Molecular Formula: C₁₈H₂₆Br₂N₂O₃
• Molecular Weight: 478.224
• Mol file: 301669-90-9.mol

Synonyms:4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol

Chemical Property of 4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol

There total 1 articles about 4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + ambroxol (18683-91-5,36557-04-7,107814-37-9) → 4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol (301669-90-9)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 30 ℃; for 6h; Cooling with ice;

Reference yield:

succinic acid 4-chlorobutyl monoester + 4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol (301669-90-9) → [4-oxo-(4-chlorobutyloxy)butanoyl-4-(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]cyclohexanol ester (301669-91-0)

Guidance literature:

succinic acid 4-chlorobutyl monoester; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 0.166667h;

4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

4-[(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]trans cyclohexanol (301669-90-9) + tert-butylchlorodiphenylsilane (58479-61-1) → C34H44Br2N2O3Si

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 50 ℃; for 6h; Temperature; Cooling with ice;

upstream raw materials:

di-tert-butyl dicarbonate

ambroxol

Downstream raw materials:

[4-oxo-(4-chlorobutyloxy)butanoyl-4-(2-tert-butoxycarbonylamino-3,5-dibromophenyl)methylamino]cyclohexanol ester

Refernces

• 1、 -. "Pharmaceutical compounds". Page/Page column 37. . Retrieved 2010/02/15.