Technology Process of N-<3-(3,5-difluorophenyl)propyl>aminoacetaldehyde dimethyl acetal
There total 9 articles about N-<3-(3,5-difluorophenyl)propyl>aminoacetaldehyde dimethyl acetal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
for 16h;
Ambient temperature;
DOI:10.1021/jm00386a008
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating
2: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating
3: 66 percent / pyridine, piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h
4: 97 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
5: 85 percent / thionyl chloride / dimethylformamide / 3 h / 60 °C
6: 100 percent / CH2Cl2 / 1 h / 0 °C
7: 88 percent / LiAlH4 / diethyl ether / 16 h / Ambient temperature
With
piperidine; pyridine; lithium aluminium tetrahydride; formic acid; thionyl chloride; hydrogen;
palladium on activated charcoal; nickel;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00386a008
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 66 percent / pyridine, piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h
2: 97 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
3: 85 percent / thionyl chloride / dimethylformamide / 3 h / 60 °C
4: 100 percent / CH2Cl2 / 1 h / 0 °C
5: 88 percent / LiAlH4 / diethyl ether / 16 h / Ambient temperature
With
piperidine; pyridine; lithium aluminium tetrahydride; thionyl chloride; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00386a008
