Chlorpheniramine Maleate

Base Information

• Chemical Name: Chlorpheniramine Maleate
• CAS No.: 2438-32-6
• Deprecated CAS: 7054-11-7
• Molecular Formula: C16H19ClN2•C4H4O4
• Molecular Weight: 390.867
• Hs Code.: 2933399090
• European Community (EC) Number: 204-037-5
• UNII: V1Q0O9OJ9Z
• ChEMBL ID: CHEMBL1659
• NCI Thesaurus Code: C28925
• NSC Number: 759156
• RXCUI: 142429
• Wikidata: Q27106157
• Mol file: 2438-32-6.mol

Synonyms:Aller-Chlor;Antihistaminico Llorens;Chlo-Amine;Chlor-100;Chlor-Trimeton;Chlor-Tripolon;Chlorphenamine;Chlorpheniramine;Chlorpheniramine Maleate;Chlorpheniramine Tannate;Chlorpro;Chlorprophenpyridamine;Chlorspan 12;Chlortab-4;Cloro-Trimeton;Efidac 24;Kloromin;Maleate, Chlorpheniramine;Piriton;Tannate, Chlorpheniramine;Teldrin

Chemical Property of Chlorpheniramine Maleate

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 6.04E-06mmHg at 25°C
• Melting Point: 112-115 °C(lit.)
• Boiling Point: 379 °C at 760 mmHg
• Flash Point: 183 °C
• PSA: 90.73000
• LogP: 3.53040
• Storage Temp.: Refrigerator
• Solubility.: Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 390.1346349
• Heavy Atom Count: 27
• Complexity: 368

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chlorpheniramine Maleate Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 36/37/39-45

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
• Recent ClinicalTrials: Chlorpheniramine Nasal Spray to Accelerate COVID-19 Clinical Recovery in an Outpatient Setting: ACCROS-III
• Recent EU Clinical Trials: A study to assess the efficacy of a combination of natural plant extracts in natural colds.
• Recent NIPH Clinical Trials: Preliminary trial of the increase of antihistamines in dose and a combination of different antihistamine on refractory spontaneous urticaria
• Uses: S-(+)-Chlorpheniramine maleate salt has been used to study the anticholinergic effect of Achillea millefolium and Portulaca olerace on muscarinic receptors of guinea pig tracheal smooth muscle. The S-enantiomer of Chlorpheniramine (C424300). Antihistaminic. bone resorption inhibitor, Antihistaminic.
• Therapeutic Function: Antihistaminic

Technology Process of Chlorpheniramine Maleate

There total 2 articles about Chlorpheniramine Maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorphenamine maleate (113-92-8) → dextrochlorpheniramine maleate (2438-32-6) + (-)-Chlorpheniramine maleate (23095-76-3)

Guidance literature:

With sodium dihydrogenphosphate; phosphoric acid; In methanol; water; pH=2.75; Reagent/catalyst; Ionic liquid; Resolution of racemate;

DOI:10.1002/chir.22168

Reference yield:

→ dextrochlorpheniramine maleate (2438-32-6)

Guidance literature:

Reference yield:

dextrochlorpheniramine maleate (2438-32-6) → S-(+)-monodesmethylchlorpheniramine

Guidance literature:

With α-D-glucose 6-phosphate; Wistar rat liver microsomes; NADP; In phosphate buffer; at 37 ℃; for 0.5h; Further Variations:; Reaction partners; Enzyme kinetics; Enzymatic reaction;

DOI:10.1111/j.2042-7158.1997.tb06791.x

upstream raw materials:

chlorphenamine maleate

Refernces

• 1、 Xu, Guangfu,Du, Yingxiang,Du, Fan,Chen, Jiaquan,Yu, Tao,Zhang, Qi,Zhang, Jinjing,Du, Shuaijing,Feng, Zijie. "Establishment and Evaluation of the Novel Tetramethylammonium-L-Hydroxyproline Chiral Ionic Liquid Synergistic System Based on Clindamycin Phosphate for Enantioseparation by Capillary Electrophoresis". supporting information. p. 598 - 604. Retrieved 2015/08/25.
• 2、 Cui, Yan,Ma, Xiaowei,Zhao, Min,Jiang, Zhen,Xu, Shuying,Guo, Xingjie. "Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis". . p. 409 - 414. Retrieved 2013/07/26.