Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides

Base Information

• Chemical Name: Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides
• CAS No.: 85409-22-9
• Molecular Formula: C17H30ClN
• Molecular Weight: 283.88000
• Hs Code.: 3402 12 00
• Mol file: 85409-22-9.mol

Synonyms:Protectol KLC 50;Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides;B 50 (surgactant);BAS 092-00E;Protectol KLC;Benzyl-C12-14-alkyldimethylammonium chlorides;Alkylbenzyldimethylammonium chlorides, benzyl-C12-14-alkyldimethyl;C12-14-alkylbenzyldimethylammonium chlorides;Protectol KLC 80;SINOTEX CDB;Benzalkonium Chloride;

Chemical Property of Quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides

Chemical Property:

• Appearance/Colour: White Powder
• Vapor Pressure: 0.001-0.006Pa at 20-50℃
• Melting Point: 73°C
• Boiling Point: 102℃ at 101.3kPa
• Flash Point: >100°C
• PSA: 0.00000
• Density: 0.96-929 at 20℃
• LogP: 1.62750
• Storage Temp.: Store below +30°C.
• Solubility.: Benzalkonium chloride is soluble in water (100 mg/ml), yielding a clear, colorless to faint yellow solution. It is also very soluble in alcohol and acetone, slightly soluble in benzene, and almost insoluble in ether.Solutions may be autoclaved or aseptically filtered.

Purity/Quality:

98%, ^*data from raw suppliers

Benzalkonium chloride BioXtra ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Benzalkonium chloride (BAC) is a compound of the class of quaternary ammonium compounds (QAC) used as a cationic surfactant in personal hygiene, cosmetic and skin disinfection products. BAC is a mixture of alkylbenzyldimethylammonium chlorides [C6H5CH2N(CH3)2RCl], in which R = C12, C14, C16, C18 are the main compounds, and the antibacterial effects being given by the alkyl chain length and the quaternary ammonium groups. Benzalkonium chloride is a quaternary ammonium antiseptic and disinfectant with actions and uses similar to those of other cationic surfactants. It is also used as an antimicrobial preservative for pharmaceutical products. For most multidose aqueous nasal, ophthalmic and otic products, benzalkonium chloride is the preservative of choice. It has been used in eye drops as a preservative since the 1950’s and it is still the most common preservative used in ophthalmic solutions at a concentration of 0.01–0.02%. It is an effective bactericidal and fungicidal agent that helps to minimise the growth of organisms in multidose containers.
• Uses: Benzalkonium chloride is a cationic detergent, like other quaternary ammonium compounds, and is used as an antiseptic agent in ophthalmic preparations, skin disinfectants, cosmetics, deodorants, mouthwashes, lozenges and solutions for contact lenses. It is also used in medications for relief of burns, scalds, cuts and local inflammation of the skin and mouth. It may also be used for infant teething and in wipes for usage for irritations around the anus. Further research may identify additional product or industrial usages of this chemical. Benzalkonium chloride is a highly concentrated quaternary ammonium antimicrobial used in a broad number of applications. Benzalkonium chloride (BAK) is a common preservative used in ophthalmic medications and is the active ingredient in some skin disinfectants and hand sanitizers. BAK is known to be effective in killing bacteria and enveloped viruses. However, its activity against non-enveloped viruses is unknown. Benzalkonium chloride (as Roccal or Zephiran) was found to inactivate influenza, measles, canine distemper, rabies, fowl laryngotracheitis, vaccinia, Semliki Forest, feline pneumonitis, meningopneumonitis, and herpes simplex viruses after 10 min of exposure at 30 C or at room temperature. Poliovirus and encephalomyocarditis virus were not inactivated under the same conditions. Benzalkonium chloride is also used as a topical anti-infective in medicine as well as a germicide for cleansing food and dairy utensils, and as a controlling agent for swimming pool algae. It is also an additive in deodorants and hairdressing preparations.
• Indications: Benzalkonium chloride is a quaternary ammonium detergent that treats grampositive and gram-negative organisms. Strains of Mycobacterium tuberculosis and Pseudomonas aeruginosa are often resistant. It is not effective against spore-forming organisms. It is nonirritating to mucous membranes and may be used near the eyes. Drawbacks include lack of sustained activity and ease of contamination of this antimicrobial. It is inactivated by anionic compounds such as soap. A 0.1% solution takes 7 minutes to decrease the bacterial count by 50%. All traces of soap must be removed with 70% alcohol before use.
• Clinical Use: Benzalkonium chloride, a quaternary ammonium compound, is found as a preservative in contact lens cleaning solutions, soaps, and skin care products and is used as a disinfectant and impregnated on medical devices to prevent bacterial colonization. Localized Cou has been described to cutaneous contact with a toilet cleaner.Parenteral and mucosal exposure has been documented to result in a generalized urticaria, respiratory compromise, and anaphylaxis. It was used as a preservative in bronchodilator nebulizer solutions; however, it was proven to cause bronchoconstriction in some asthmatic patients and a call for its withdrawal from these products occurred in 2001.Whether these effects are related to an IgE-mediated mechanism has not been established. Bernstein et al. describe a case of combined occupational asthma and localized and generalized Cou to contact with benzalkonium chloride in a toilet cleaner. They could not show benzalkonium chloride-specific IgE antibodies in the serum of this patient. Benzalkonium chloride in nasal drops,eye drops,nebulizer solution,and a benzalkonium-coated central venous catheter have been documented to cause immediate generalized reactions and anaphylaxis.