2-(3,5-dimethoxyphenyl)-5-methylfuran

Base Information

• Chemical Name: 2-(3,5-dimethoxyphenyl)-5-methylfuran
• CAS No.: 1262588-86-2
• Molecular Formula: C₁₃H₁₄O₃
• Molecular Weight: 218.252
• Mol file: 1262588-86-2.mol

Synonyms:2-(3,5-dimethoxyphenyl)-5-methylfuran

Chemical Property of 2-(3,5-dimethoxyphenyl)-5-methylfuran

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-dimethoxyphenyl)-5-methylfuran

There total 2 articles about 2-(3,5-dimethoxyphenyl)-5-methylfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-methylfuran (534-22-5) + 1-chloro-3,5-dimethoxybenzene (7051-16-3) → 2-(3,5-dimethoxyphenyl)-5-methylfuran (1262588-86-2)

Guidance literature:

With potassium phosphate; palladium diacetate; CyJohnPhos; In 1-methyl-pyrrolidin-2-one; at 15 - 100 ℃; for 24.25h; Inert atmosphere;

DOI:10.1021/jo1018969

Reference yield: 46.0%

5-methylfuran-2-boronic acid (62306-79-0) + 1-bromo-3,5-dimethoxybenzene (20469-65-2) → 2-(3,5-dimethoxyphenyl)-5-methylfuran (1262588-86-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 80 - 110 ℃; for 17h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201310985

Reference yield: 12.0%

2-(3,5-dimethoxyphenyl)-5-methylfuran (1262588-86-2) + Ethyl oxalyl chloride (4755-77-5) → C17H18O6 + C17H18O6

Guidance literature:

With aluminum (III) chloride; at 20 ℃;

DOI:10.1016/j.tetlet.2018.04.027

upstream raw materials:

2-methylfuran

1-chloro-3,5-dimethoxybenzene

5-methylfuran-2-boronic acid

1-bromo-3,5-dimethoxybenzene

Downstream raw materials:

2-(3,5-dimethoxyphenyl)-5-methyltetrahydrofuran

2-(3,5-dimethoxyphenyl)-5-methyltetrahydrofuran

Refernces

• 1、 Nadres, Enrico T.,Lazareva, Anna,Daugulis, Olafs. "Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides". experimental part. p. 471 - 483. Retrieved 2011/04/15.