4,7,10-Trioxa-1,13-tridecanediamine

Base Information

• Chemical Name: 4,7,10-Trioxa-1,13-tridecanediamine
• CAS No.: 4246-51-9
• Deprecated CAS: 849801-57-6,1438397-27-3,678186-55-5,1425007-66-4
• Molecular Formula: C10H24 N2 O3
• Molecular Weight: 220.312
• Hs Code.: 2922199090
• European Community (EC) Number: 224-207-2,692-513-7
• UNII: 95W232H4RT
• DSSTox Substance ID: DTXSID6044565
• Nikkaji Number: J13.690E
• Wikidata: Q27271827
• ChEMBL ID: CHEMBL3187499
• Mol file: 4246-51-9.mol

Synonyms:4246-51-9;4,7,10-Trioxa-1,13-tridecanediamine;3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine);Bis-NH2-C1-PEG3;Diethylene Glycol Bis(3-aminopropyl) Ether;PROTAC Linker 24;3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propan-1-amine;4,7,10-trioxatridecane-1,13-diamine;3,3'-Oxybis(ethyleneoxy)bis(propylamine);C10H24N2O3;Di(3-aminopropyl) ether of diethylene glycol;EINECS 224-207-2;DIETHYLENE GLYCOL, DI(3-AMINOPROPYL) ETHER;BRN 1760709;3,3'-[Oxybis(2,1-ethanediyloxy)]bis-1-propanamine;Propylamine-PEG3-Propylamine;1-Propanamine, 3,3'-(oxybis(2,1-ethanediyloxy))bis-;1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-;UNII-95W232H4RT;DTXSID6044565;95W232H4RT;Q 19262;3,3'-(Oxybis(2,1-ethanediyloxy))bis-1-propanamine;3,3'-[OXYBIS(ETHANE-2,1-DIYLOXY)]DIPROPAN-1-AMINE;O,O'-Bis(3-aminopropyl)diethylene glycol;Trioxa-1,13-tridecanediamine,4,7,10-,;EC 224-207-2;3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}-1-propanamine;Bis[2-(3-aminopropoxy)ethyl] Ether;MFCD00059850;BIS(2-(3-AMINOPROPOXY)ETHYL) ETHER;Propylamine, 3,3'-[oxybis(ethyleneoxy)]bis-;PROPYLAMINE, 3,3'-(OXYBIS(ETHYLENEOXY))BIS-;3,3'-(OXYBIS(ETHANE-2,1-DIYLOXY))DIPROPAN-1-AMINE;3-{2-[2-(3-AMINOPROPOXY)ETHOXY]ETHOXY}PROPAN-1-AMINE;DPA-DEG;ANCAMINE 1922;SCHEMBL25842;CHEMBL3187499;DTXCID4024565;Tox21_301509;AKOS000348730;C10-H24-N2-O3;AT11312;1,13-diamino-4,7,10-trioxatridecane;Diethylene glycol di (aminopropyl) ether;NCGC00255812-01;4,7,10-trioxa-1,13-tridecane diamine;4,7,10-Trioxatridecane- 1,13-diamine;BP-23734;BS-17252;LS-61882;CAS-4246-51-9;Diethylene glycol-bis(3-aminopropyl) ether;HY-128844;BB 0217999;CS-0077127;D1571;FT-0689302;4,7,10-TRIOXA-1,13-TRIDECANAMINE;4,7,10-Trioxa-1,13-tridecanediamine, 97%;EN300-383885;1-Propylamine, 3,3'-(oxybis(ethyleneoxy))bis-;Q-19262;W-109959;Q27271827;4,7,10-Trioxatridecan-1,13-diamine (Baxxodur? EC 130);1-Propylamine, 3,3'-(oxybis(ethyleneoxy))bis- (6CI,7CI,8CI);3,3'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))dipropan-1-amine

Chemical Property of 4,7,10-Trioxa-1,13-tridecanediamine

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Vapor Pressure: 0.000594mmHg at 25°C
• Melting Point: -32 °C
• Refractive Index: n20/D 1.464(lit.)
• Boiling Point: 310.6 °C at 760 mmHg
• PKA: 10.00±0.10(Predicted)
• Flash Point: 148 °C
• PSA: 79.73000
• Density: 1.001 g/cm³
• LogP: 1.13440
• Storage Temp.: Store below +30°C.
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• Exact Mass: 220.17869263
• Heavy Atom Count: 15
• Complexity: 103

Purity/Quality:

99%+ ^*data from raw suppliers

3,3’-[Oxybis(2,1-ethanediyloxy)]bis[1-propanamine] ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: C(CN)COCCOCCOCCCN

Technology Process of 4,7,10-Trioxa-1,13-tridecanediamine

There total 7 articles about 4,7,10-Trioxa-1,13-tridecanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-(2-hydroxyethoxy)ethoxy)propanenitrile (10143-54-1) + bis(2-(2-cyanoethoxy)ethyl)ether (22397-31-5) → 4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) + 2-[2-(3-amino-propoxy)-ethoxy]-ethanol (112-33-4)

Guidance literature:

With hydrogen; Grace 2724 sponge cobalt; In tert-butyl methyl ether; at 120 ℃; for 5h; under 42133 Torr; Product distribution / selectivity;

Reference yield:

3-(2-(2-hydroxyethoxy)ethoxy)propanenitrile (10143-54-1) + bis(2-(2-cyanoethoxy)ethyl)ether (22397-31-5) → aminopropyldiaminopropyldiethyleneglycol + C16H38N4O3 + 4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) + 2-[2-(3-amino-propoxy)-ethoxy]-ethanol (112-33-4)

Guidance literature:

With hydrogen; Grace 2724 sponge cobalt; In methanol; at 120 ℃; for 5h; under 42133 Torr; Product distribution / selectivity;

Reference yield:

3-(2-(2-hydroxyethoxy)ethoxy)propanenitrile (10143-54-1) + bis(2-(2-cyanoethoxy)ethyl)ether (22397-31-5) → aminopropyldiaminopropyldiethyleneglycol + 4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) + 2-[2-(3-amino-propoxy)-ethoxy]-ethanol (112-33-4)

Guidance literature:

With hydrogen; Grace 2724 sponge cobalt; at 125 ℃; for 4h; under 47304.6 Torr; Product distribution / selectivity;

upstream raw materials:

bis(2-(2-cyanoethoxy)ethyl)ether

3-(2-(2-hydroxyethoxy)ethoxy)propanenitrile

2-[2-[2-[2-aminoethoxy]ethoxy]ethoxy]ethylamine

1⁽⁴⁾-methoxy-7,10,13-trioxa-3,17-diaza-1(2,6)-pyridinaoctadecacyclophan-2,17-diene

Downstream raw materials:

1,15-Diphenyl-6,9,12-trioxa-2,16-diazaheptadecane

1,13-Trioxa-SA-pTyr-γ-p-azidoGlu-Glu-Ile-OH

NH₂-1,13-Trioxa-Suc-Y(PO₃H₂)EEI

N-(3-{2-[2-(3-amino-propoxy)-ethoxy]-ethoxy}-propyl)-N',N''-bis-(4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine

Refernces

• 1、 -. "Aminopropylation of alcohols in the presence of amide or ether solvents". Page/Page column 3; 6. . Retrieved 2008/06/13.