Technology Process of 5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid
There total 10 articles about 5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 5-(4-(((9H-fluoren-9-yl)methoxy)carbonylamino)phenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylate;
With
lithium hydroxide;
In
1,4-dioxane; water;
at 20 - 60 ℃;
for 0.416667h;
With
hydrogenchloride;
In
1,4-dioxane; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: water / 0.17 h / 20 °C
1.2: 2 h / Heating / reflux
1.3: pH 4
2.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 5 h / Heating / reflux
3.1: ammonia / ethanol / 20 h / 130 °C
4.1: toluene / 3 h / Heating / reflux
5.1: acetic acid / 0.5 h / 140 °C
6.1: lithium hydroxide / 1,4-dioxane; water / 0.42 h / 20 - 60 °C
With
lithium hydroxide; tetrabutylammomium bromide; ammonia; phosphorus pentoxide;
In
1,4-dioxane; ethanol; water; acetic acid; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium / diethyl ether / 0 - 20 °C
2.1: water / 0.17 h / 20 °C
2.2: 2 h / Heating / reflux
2.3: pH 4
3.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 5 h / Heating / reflux
4.1: ammonia / ethanol / 20 h / 130 °C
5.1: toluene / 3 h / Heating / reflux
6.1: acetic acid / 0.5 h / 140 °C
7.1: lithium hydroxide / 1,4-dioxane; water / 0.42 h / 20 - 60 °C
With
lithium hydroxide; tetrabutylammomium bromide; ammonia; sodium; phosphorus pentoxide;
In
1,4-dioxane; diethyl ether; ethanol; water; acetic acid; toluene;