2-methyl-5-phenyl-2h-tetrazole

Base Information

• Chemical Name: 2-methyl-5-phenyl-2h-tetrazole
• CAS No.: 20743-49-1
• Molecular Formula: C8H8 N4
• Molecular Weight: 160.178
• Hs Code.: 2933990090
• Mol file: 20743-49-1.mol

Synonyms:2-Methyl-5-phenyl-2H-tetrazole;2-Methyl-5-phenyltetrazole; NSC 314080

Chemical Property of 2-methyl-5-phenyl-2h-tetrazole

Chemical Property:

• Vapor Pressure: 0.000501mmHg at 25°C
• Boiling Point: 313.3°Cat760mmHg
• Flash Point: 143.3°C
• PSA: 43.60000
• Density: 1.24g/cm³
• LogP: 0.87710

Purity/Quality:

98%min ^*data from raw suppliers

MC000324:2-Methyl-5-phenyl-2H-tetrazole 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-5-phenyl-2h-tetrazole

There total 39 articles about 2-methyl-5-phenyl-2h-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole (131183-01-2) + 4-bromo-benzaldehyde (1122-91-4) → 2-methyl-5-phenyl-2H-tetrazole (20743-49-1) + 1-(4-bromophenyl)-2-(5-phenyl-2H-tetrazol-2-yl)ethanol

Guidance literature:

5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole; 4-bromo-benzaldehyde; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 35 ℃; for 19h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; at 20 ℃; for 0.5h;

DOI:10.3987/COM-14-13077

Reference yield: 87.0%

5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole (131183-01-2) + benzaldehyde (100-52-7) → 2-methyl-5-phenyl-2H-tetrazole (20743-49-1) + 1-phenyl-2-(5-phenyl-2H-tetrazol-2-yl)ethan-1-ol (93742-47-3)

Guidance literature:

5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole; benzaldehyde; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 35 ℃; for 19h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; at 20 ℃; for 0.5h; Reagent/catalyst; Solvent;

DOI:10.3987/COM-14-13077

Reference yield: 85.0%

(E)-3-phenylpropenal (14371-10-9) + 5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole (131183-01-2) → 2-methyl-5-phenyl-2H-tetrazole (20743-49-1) + (E)-4-phenyl-1-(5-phenyl-2H-tetrazol-2-yl)but-3-en-2-ol

Guidance literature:

(E)-3-phenylpropenal; 5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 35 ℃; for 19h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; at 20 ℃; for 0.5h;

DOI:10.3987/COM-14-13077

upstream raw materials:

5-Phenyl-1H-tetrazole

1-methyl-4-nitrosobenzene

acetone

methyl iodide

Downstream raw materials:

styrene

N-((methylimino)methylene)aniline

benzonitrile

Refernces

• 1、 Monti, Filippo,Baschieri, Andrea,Gualandi, Isacco,Serrano-Perez, Juan J.,Junquera-Hernandez, Jose M.,Tonelli, Domenica,Mazzanti, Andrea,Muzzioli, Sara,Stagni, Stefano,Roldan-Carmona, Cristina,Pertegas, Antonio,Bolink, Henk J.,Orti, Enrique,Sambri, Letizia,Armaroli, Nicola. "Iridium(III) complexes with phenyl-tetrazoles as cyclometalating ligands". . p. 7709 - 7721. Retrieved 2014.
• 2、 -. "ACLY INHIBITORS AND USES THEREOF". Paragraph 00409. . Retrieved 2020/06/01.
• 3、 Yan, Yu-Hang,Chen, Jian,Zhan, Zhen,Yu, Zhu-Jun,Li, Gen,Guo, Li,Li, Guo-Bo,Wu, Yong,Zheng, Yongxiang. "Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors". . p. 31377 - 31384. Retrieved 2020/09/21.