Nitrosulfathiazole

Base Information

• Chemical Name: Nitrosulfathiazole
• CAS No.: 473-42-7
• Molecular Formula: C9H7 N3 O4 S2
• Molecular Weight: 285.304
• UNII: FO9CU4TX7J
• DSSTox Substance ID: DTXSID10197091
• Nikkaji Number: J10.630E
• Wikidata: Q27278106
• NCI Thesaurus Code: C170225
• ChEMBL ID: CHEMBL593262
• Mol file: 473-42-7.mol

Synonyms:Nitrosulfathiazole;473-42-7;para-Nitrosulfathiazole;p-Nitrosulfathiazole;Nisulfazole;4-nitro-N-(1,3-thiazol-2-yl)benzenesulfonamide;Nisulfazol;Nitrosulfatiazol;Nitrosulfathiazole [INN];Sulfanitrothiazole;Nitrosulfathiazolum;UNII-FO9CU4TX7J;FO9CU4TX7J;Para-nitrosulfathiazole [NF];2-(p-Nitrophenylsulfonamido)thiazole;p-Nitro-N-2-thiazolylbenzenesulfonamide;4-Nitro-N-(2-thiazolyl)benzolsulfonamid;SR-01000945161;Nitrosulfathiazol;Oprea1_119305;Oprea1_516228;MLS006011408;SCHEMBL338503;CHEMBL593262;DTXSID10197091;Para-Nitrosulfathiazole [NF XI];STL260521;AKOS000668688;SMR002530487;Benzenesulfonamide, 4-nitro-N-2-thiazolyl-;Benzenesulfonamide, p-nitro-N-2-thiazolyl-;SR-01000945161-1;SR-01000945161-2;Q27278106;4-NITRO-N-(1,3-THIAZOL-2-YL)-1-BENZENESULFONAMIDE

Chemical Property of Nitrosulfathiazole

Chemical Property:

• Vapor Pressure: 6.11E-10mmHg at 25°C
• Boiling Point: 495°Cat760mmHg
• Flash Point: 253.2°C
• PSA: 141.50000
• Density: 1.648g/cm³
• LogP: 3.52910
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 284.98779806
• Heavy Atom Count: 18
• Complexity: 395

Purity/Quality:

99% ^*data from raw suppliers

NITROSULFATHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)NC2=NC=CS2

Technology Process of Nitrosulfathiazole

There total 4 articles about Nitrosulfathiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-thiazolylamine (96-50-4) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → Nisulfazole (473-42-7)

Guidance literature:

With pyridine; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2009.09.030

Reference yield:

4-nitro-benzenesulfenic acid thiazol-2-ylamide → Nisulfazole (473-42-7)

Guidance literature:

With potassium permanganate; acetic acid;

Reference yield:

4-nitro-benzenesulfinic acid thiazol-2-ylamide → Nisulfazole (473-42-7)

Guidance literature:

With potassium hydroxide; potassium permanganate; potassium carbonate;

upstream raw materials:

2-thiazolylamine

4-Nitrobenzenesulfonyl chloride

4-nitro-benzenesulfinyl chloride

Downstream raw materials:

N-{1-methyl-3-[2-(4-phenoxy-phenoxy)-thiazol-5-yl]-prop-2-ynyl}-4-nitro-N-thiazol-2-yl-benzenesulfonamide

4-nitro-benzenesulfonic acid-(methyl-thiazol-2-yl-amide)

4-nitro-N-(3-xanthen-9-yl-3H-thiazol-2-ylidene)-benzenesulfonamide

Sulfathiazole

Refernces

• 1、 Galiana-Roselló, Cristina,Bilbao-Ramos, Pablo,Dea-Ayuela, M. Auxiliadora,Rolón, Miriam,Vega, Celeste,Bolás-Fernández, Francisco,García-Espa?a, Enrique,Alfonso, Jorge,Coronel, Cathia,González-Rosende, M. Eugenia. "In vitro and in vivo antileishmanial and trypanocidal studies of new N -benzene- and N -naphthalenesulfonamide derivatives". . p. 8984 - 8998. Retrieved 2014/01/06.
• 2、 -. "PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM". Page/Page column 15. . Retrieved 2009/03/07.