(R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine

Base Information

• Chemical Name: (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine
• CAS No.: 72522-20-4
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.199
• Mol file: 72522-20-4.mol

Synonyms:(R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine

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Chemical Property of (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine

There total 19 articles about (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

4-fluorophenyl acetone (459-03-0) + 2-Pentanone (107-87-9) → (R)‐2‐aminopentane (625-30-9,33985-20-5,54542-13-1,63493-28-7) + (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine (72522-20-4)

Guidance literature:

With Candida boidinii formate dehydrogenase; pyridoxal 5'-phosphate; Aspergillus terreus ω-trans aminase; Lysinibacillus fusiformis leucine dehydrogenase; ammonium formate; nicotinamide adenine dinucleotide; In aq. buffer; at 30 ℃; for 24h; pH=8.8; Catalytic behavior; Green chemistry; Enzymatic reaction;

DOI:10.1021/acs.joc.9b02445

Reference yield: 99.4%

4-fluorophenyl acetone (459-03-0) → (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine (72522-20-4)

Guidance literature:

With Candida boidinii formate dehydrogenase; pyridoxal 5'-phosphate; ammonium formate; nicotinamide adenine dinucleotide; In aq. buffer; at 30 ℃; for 24h; pH=8.8; Green chemistry; Enzymatic reaction;

DOI:10.1021/acs.joc.9b02445

Reference yield: 72.0%

C12H16FNO2 (1351781-71-9) → (R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine (72522-20-4)

Guidance literature:

With water; potassium hydroxide; optical yield given as %ee; Reflux;

DOI:10.1039/c1ob06251d

upstream raw materials:

(R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)ethylamine hydrochloride

C₁₂H₁₆FNO₂

ethyl 2-methoxyacetate

4-fluoroamphetamine

Downstream raw materials:

(R)-N-(1-(4-fluorophenyl)propan-2-yl)acetamide

(R)-(-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine

(R)-(-)-α-methyl-β-(4-fluorophenyl)-N-methyl-N-propynylethylamine

Refernces

• 1、 Mu, Xiaoqing,Wu, Tao,Mao, Yong,Zhao, Yilei,Xu, Yan,Nie, Yao. "Iterative Alanine Scanning Mutagenesis Confers Aromatic Ketone Specificity and Activity of L-Amine Dehydrogenases". . p. 5243 - 5253. Retrieved 2021/11/16.
• 2、 Kadkhodaei, Kian,Kadisch, Marlene,Schmid, Martin G.. "Successful use of a novel lux i-Amylose-1 chiral column for enantioseparation of “legal highs” by HPLC". . p. 42 - 52. Retrieved 2019/11/14.