2,3-Dimethylpyrido[2,3-b]pyrazine

Base Information

• Chemical Name: 2,3-Dimethylpyrido[2,3-b]pyrazine
• CAS No.: 7154-32-7
• Molecular Formula: C9H9N3
• Molecular Weight: 159.1879
• NSC Number: 73507
• DSSTox Substance ID: DTXSID70291145
• Nikkaji Number: J2.816.921C
• Wikidata: Q82029003
• ChEMBL ID: CHEMBL1892443
• Mol file: 7154-32-7.mol

Synonyms:2,3-dimethylpyrido[2,3-b]pyrazine;7154-32-7;MLS000736808;2,3-dimethylpyrido(2,3-b)pyrazine;NSC73507;SCHEMBL1616244;CHEMBL1892443;DTXSID70291145;HMS2885E05;MFCD03012163;NSC 73507;NSC-73507;AKOS003390004;SMR000528332;3T-0629

Chemical Property of 2,3-Dimethylpyrido[2,3-b]pyrazine

Chemical Property:

• Vapor Pressure: 0.0128mmHg at 25°C
• Melting Point: 143-144 °C
• Boiling Point: 268.3°C at 760 mmHg
• PKA: 1.97±0.30(Predicted)
• Flash Point: 116.1°C
• PSA: 38.67000
• Density: 1.172g/cm³
• LogP: 1.64160
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 159.079647300
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

2,3-DIMETHYLPYRIDO(2,3-B)PYRAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C2C(=N1)C=CC=N2)C

Technology Process of 2,3-Dimethylpyrido[2,3-b]pyrazine

There total 7 articles about 2,3-Dimethylpyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-Diaminopyridine (452-58-4) + dimethylglyoxal (431-03-8) → dimethyl-2,3 pyrido<2,3-b>pyrazine (7154-32-7)

Guidance literature:

With zirconium(IV) chloride; In methanol; at 20 ℃; for 0.0833333h;

DOI:10.1007/s11243-009-9294-9

Reference yield: 79.0%

2,3-Diaminopyridine (452-58-4) + 3-hydroxy-2-butanon (513-86-0,52217-02-4,51555-24-9) → dimethyl-2,3 pyrido<2,3-b>pyrazine (7154-32-7)

Guidance literature:

With hexaammonium heptamolybdate tetrahydrate; at 90 ℃; for 0.25h; Catalytic behavior; Microwave irradiation;

DOI:10.1016/j.crci.2012.06.007

Reference yield: 70.0%

2,3-Diaminopyridine (452-58-4) + 2.3-butanediol (513-85-9) → dimethyl-2,3 pyrido<2,3-b>pyrazine (7154-32-7)

Guidance literature:

With C₁₈H₂₄ClIrN₃O⁽¹⁺⁾*Cl^(1-); potassium hydroxide; In water; for 24h; Schlenk technique; Reflux; Green chemistry;

DOI:10.1039/c8gc03744b

upstream raw materials:

2,3-Diaminopyridine

dimethylglyoxal

7-bromo-2,3-dimethylpyrido<2,3-b>pyrazine

2,2'-iminobis[ethanol]

Downstream raw materials:

5-Benzoyl-6-cyano-2,3-dimethyl-5,6-dihydropyrido<2,3-b>pyrazine

Refernces

• 1、 Chakrabarti, Kaushik,Maji, Milan,Kundu, Sabuj. "Cooperative iridium complex-catalyzed synthesis of quinoxalines, benzimidazoles and quinazolines in water". supporting information. p. 1999 - 2004. Retrieved 2019/04/27.
• 2、 Xiong, Biao,Zhang, Shu-Di,Chen, Lu,Li, Bin,Jiang, Huan-Feng,Zhang, Min. "An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives". supporting information. p. 10636 - 10639. Retrieved 2016/09/02.