6-Methoxyflavanone

Base Information

• Chemical Name: 6-Methoxyflavanone
• CAS No.: 3034-04-6
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Hs Code.: 29329900
• NSC Number: 50184
• Nikkaji Number: J285.122I
• Wikidata: Q106902820
• Metabolomics Workbench ID: 74408
• ChEMBL ID: CHEMBL476292
• Mol file: 3034-04-6.mol

Synonyms:6-methoxyflavanone

Chemical Property of 6-Methoxyflavanone

Chemical Property:

• Appearance/Colour: slightly yellowish-green crystalline powder
• Vapor Pressure: 1.91E-07mmHg at 25°C
• Melting Point: 141-143 °C(lit.)
• Boiling Point: 425.5°Cat760mmHg
• Flash Point: 202.9°C
• PSA: 35.53000
• Density: 1.199g/cm³
• LogP: 3.40170
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 254.094294304
• Heavy Atom Count: 19
• Complexity: 322

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methoxyflavanone 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)OC(CC2=O)C3=CC=CC=C3

Technology Process of 6-Methoxyflavanone

There total 26 articles about 6-Methoxyflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-1-(2-hydroxy-5-methoxyphenyl)-3-phenylprop-2-en-1-one (3033-90-7,99430-03-2) → 6-methoxyflavanone (3034-04-6,84963-03-1,99493-45-5)

Guidance literature:

In ethanol; pH=9.25; Kinetics;

DOI:10.1039/c4ob00398e

Reference yield: 90.0%

4-methoxy-2-(3-phenyl-1-(piperidin-1-yl)prop-2-yn-1-yl)phenol → 6-methoxyflavanone (3034-04-6,84963-03-1,99493-45-5)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 80 ℃; for 1h;

DOI:10.1021/acs.orglett.0c01357

Reference yield: 89.0%

2'-hydroxy-5'-methoxychalcone (99430-03-2,3033-90-7) → 6-methoxyflavanone (3034-04-6,84963-03-1,99493-45-5)

Guidance literature:

With 1-methyl-1H-imidazole; In dimethyl sulfoxide; at 80 ℃; for 6h;

DOI:10.2298/JSC120629157W

upstream raw materials:

(E)-1-(2-hydroxy-5-methoxyphenyl)-3-phenylprop-2-en-1-one

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

benzaldehyde

(E)-4-methoxyphenyl cinnamate

Downstream raw materials:

3-ferrocenylmethylidenyl-6-methoxy-2-phenylchroman-4-one

8-methoxy-4-phenyl-4H-benzopyran[4,3-d][1,2,3]selenadiazole

C₁₇H₁₇N₃O₃

6-methoxy-2-phenylchroman-4-one

Refernces

• 1、 Gnyawali, Krishna,Kirinde Arachchige, Pandula T.,Yi, Chae S.. "Synthesis of Flavanone and Quinazolinone Derivatives from the Ruthenium-Catalyzed Deaminative Coupling Reaction of 2′-Hydroxyaryl Ketones and 2-Aminobenzamides with Simple Amines". supporting information. . Retrieved 2022/01/15.
• 2、 He, Xinwei,He, Xinwei,Xie, Mengqing,Li, Ruxue,Choy, Pui Ying,Tang, Qiang,Shang, Yongjia,Kwong, Fuk Yee. "Organocatalytic Approach for Assembling Flavanones via a Cascade 1,4-Conjugate Addition/oxa-Michael Addition between Propargylamines with Water". supporting information. p. 4306 - 4310. Retrieved 2020/06/05.