sitagliptin oxalate

Base Information

• Chemical Name: sitagliptin oxalate
• CAS No.: 1169707-36-1
• Molecular Formula: C₂H₂O₄*C₁₆H₁₅F₆N₅O
• Molecular Weight: 497.354
• Mol file: 1169707-36-1.mol

Synonyms:sitagliptin oxalate

Chemical Property of sitagliptin oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sitagliptin oxalate

There total 4 articles about sitagliptin oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-3-[[(1S)-1-phenylethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one oxalate → sitagliptin oxalate (1169707-36-1)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In isopropyl alcohol; at 70 ℃; for 3h; Autoclave; Large scale;

Reference yield:

oxalic acid (144-62-7,97993-78-7) + sitagliptin (486460-32-6,823817-55-6) → sitagliptin oxalate (1169707-36-1)

Guidance literature:

In water; isopropyl alcohol; at 30 ℃; Reflux;

Reference yield:

1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione (764667-65-4) → sitagliptin oxalate (1169707-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; methanol / 1.5 h / 0 °C

2.1: acetic anhydride; sodium acetate / toluene / 6 h / Reflux

2.2: 24 h / 80 °C

2.3: 80 °C

3.1: hydrogen; 5%-palladium/activated carbon / isopropyl alcohol / 3 h / 70 °C / Autoclave; Large scale

With methanol; sodium tetrahydroborate; 5%-palladium/activated carbon; hydrogen; sodium acetate; acetic anhydride; In isopropyl alcohol; toluene;

upstream raw materials:

oxalic acid

sitagliptin

1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione

(R/S)-3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Downstream raw materials:

sitagliptin phosphate

Refernces

• 1、 -. "SOLID STATE FORMS OF SITAGLIPTIN SALTS". Page/Page column 10. . Retrieved 2010/10/19.