CID 3275884

Base Information

• Chemical Name: CID 3275884
• CAS No.: 7365-45-9
• Molecular Formula: C8H18N2O4S
• Molecular Weight: 238.308
• Hs Code.: DERIVATION
• Mol file: 7365-45-9.mol

Synonyms:

Chemical Property of CID 3275884

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0Pa at 25℃
• Melting Point: 234-238 °C
• Refractive Index: n20/D 1.339
• Boiling Point: 408℃[at 101 325 Pa]
• PKA: 7.5(at 25℃)
• PSA: 89.46000
• Density: 1.325 g/cm³
• LogP: -0.55930
• Storage Temp.: 2-8°C
• Solubility.: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility.: Soluble
• XLogP3: -4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 238.09872823
• Heavy Atom Count: 15
• Complexity: 254

Purity/Quality:

98% ^*data from raw suppliers

4-(2-Hydroxyethyl)-1-piperazineethanesulfonicacid,99-101%(Assaybytitration) 99-101%(Assaybytitration) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-22-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(CC[NH+]1CCS(=O)(=O)[O-])CCO
• Description: HEPES has been described as one of the best all-purpose buffers available for biological research. At biological pH, the molecule is zwitterionic, and is effective as a buffer at pH 6.8 to 8.2 (pKa 7.55). It is typically used in cell culture at concentration between 5mM to 30 mM. HEPES has been used in a wide variety of applications, including tissue culture. It is commonly used to buffer cell culture media in air. HEPES finds its usage in in vitro experiments on Mg.
• Uses: Non-toxic to cell. It is used as a hydrogen ion buffer, which can control the constant pH range for long term. The concentration is 10-50mmol/L. Generally, 20mmol/LHEPES in nutrient solution can get buffer ability. HEPES is common buffer for biological sciences, particularly used in cell culture to maintain physiological pH. It acts a buffering component, which is used in the preparation of buffers. It is described as one of the best all-purpose buffers available for use in biological research.HEPES has been used as a component of:Hank′s balanced salt solution, Dulbecco′s modified eagle′s medium and no-glucose DMEM, which are used for the preparation of tissue slices.Buffers used in localized conductance measurements on the basolateral side of culture inserts to examine cation selectivity.

Technology Process of CID 3275884

There total 7 articles about CID 3275884 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

1-(2-hydroxyethyl)piperazine (103-76-4) + sodium 2-hydroxyethanesulfonate (1562-00-1) → N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (7365-45-9)

Guidance literature:

1-(2-hydroxyethyl)piperazine; sodium 2-hydroxyethanesulfonate; In methanol; at 50 ℃; for 5.5h;

With 5percent by weight of raffinate; In water; Solvent; Temperature;

Reference yield: 84.7%

1-(2-hydroxyethyl)piperazine (103-76-4) + Na-salt of 2-chloroethane-1-sulfonic acid (15484-44-3) → N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (7365-45-9)

Guidance literature:

In water; at 85 - 105 ℃; for 0.5h; pH=10; Temperature;

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) + ammonium vinylsulfonate (86761-62-8) → N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (7365-45-9)

Guidance literature:

1-(2-hydroxyethyl)piperazine; ammonium vinylsulfonate; In water; at 60 ℃; for 4h;

With sulfuric acid; at 0 ℃; for 1h;

upstream raw materials:

1-(2-hydroxyethyl)piperazine

sodium 2-hydroxyethanesulfonate

ammonium vinylsulfonate

sodium vinylsulfonate

Downstream raw materials:

2'-deoxyguanosine 5'-monophosphate

Refernces

• 1、 -. "Method for preparing high-purity 4-hydroxyethylpiperazine ethanesulfonic acid". Paragraph 0034; 0035; 0047. . Retrieved 2017/07/19.
• 2、 -. "COAGULATION FACTOR VII POLYPEPTIDES". Page/Page column. . Retrieved 2015/04/21.