trans-methyl 4-(4-bromophenyl)but-2-enoate

Base Information

• Chemical Name: trans-methyl 4-(4-bromophenyl)but-2-enoate
• CAS No.: 1310810-17-3
• Molecular Formula: C₁₁H₁₁BrO₂
• Molecular Weight: 255.111
• Mol file: 1310810-17-3.mol

Synonyms:trans-methyl 4-(4-bromophenyl)but-2-enoate

Chemical Property of trans-methyl 4-(4-bromophenyl)but-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of trans-methyl 4-(4-bromophenyl)but-2-enoate

There total 1 articles about trans-methyl 4-(4-bromophenyl)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-allyl-4-bromo-benzene (2294-43-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → trans-methyl 4-(4-bromophenyl)but-2-enoate (1310810-17-3)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; copper(l) iodide; In tetrahydrofuran; at 40 ℃; for 3h; Inert atmosphere;

Reference yield: 98.0%

N-Methyl-N'-nitro-N-nitrosoguanidine (70-25-7) + trans-methyl 4-(4-bromophenyl)but-2-enoate (1310810-17-3) → trans-methyl 2-(4-bromobenzyl)cyclopropanecarboxylate

Guidance literature:

N-Methyl-N'-nitro-N-nitrosoguanidine; With potassium hydroxide; In diethyl ether; at 0 ℃; for 0.25h;

trans-methyl 4-(4-bromophenyl)but-2-enoate; With palladium diacetate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h;

Reference yield:

trans-methyl 4-(4-bromophenyl)but-2-enoate (1310810-17-3) → trans-(2-(4-bromobenzyl)cyclopropyl)methanol

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / diethyl ether / 0.25 h / 0 °C

1.2: 1 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

With lithium aluminium tetrahydride; potassium hydroxide; In tetrahydrofuran; diethyl ether;

upstream raw materials:

1-allyl-4-bromo-benzene

acrylic acid methyl ester

Refernces