2'-HYDROXYFLAVANONE

Base Information

• Chemical Name: 2'-HYDROXYFLAVANONE
• CAS No.: 35244-11-2
• Molecular Formula: C15H10 O3
• Molecular Weight: 238.243
• Hs Code.: 2914501900
• Mol file: 35244-11-2.mol

Synonyms:Flavone,2'-hydroxy- (7CI); 2'-Hydroxyflavone

Chemical Property of 2'-HYDROXYFLAVANONE

Chemical Property:

• Melting Point: 238.5 °C
• Boiling Point: 376.9°Cat760mmHg
• PKA: 8.01±0.30(Predicted)
• Flash Point: 142.6°C
• PSA: 50.44000
• Density: 1.288g/cm³
• LogP: 3.16560

Purity/Quality:

99% ^*data from raw suppliers

2''-Hydroxyflavone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2''-Hydroxyflavone is bronchodilators and anti-inflammatory.

Technology Process of 2'-HYDROXYFLAVANONE

There total 16 articles about 2'-HYDROXYFLAVANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2'-methoxyflavone (19725-47-4) → 2'-hydroxyflavone (35244-11-2)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1002/asia.201402876

Reference yield: 55.0%

2',2-dihydroxychalcone (34000-30-1,15131-80-3) → 2'-hydroxyflavone (35244-11-2)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 140 ℃; for 2h;

DOI:10.1016/j.bioorg.2014.11.008

Reference yield:

→ 2'-hydroxyflavone (35244-11-2)

Guidance literature:

With hydrogenchloride; sodium nitrite; Diazotization;

upstream raw materials:

2-methoxybenzoic acid methyl ester

1-(2-ethoxyphenyl)ethanone

2'-methoxyflavone

methyl-2-<(tert-butyldimethylsilyl)oxy>benzoate

Downstream raw materials:

frutinone A

6-(2-oxo-2-phenylethyl)chromeno[4,3-b]chromen-7(6H)-one

Refernces

• 1、 Saito, Yohei,Mizokami, Atsushi,Tsurimoto, Hiroyuki,Izumi, Kouji,Goto, Masuo,Nakagawa-Goto, Kyoko. "5′-Chloro-2,2′-dihydroxychalcone and related flavanoids as treatments for prostate cancer". supporting information. p. 1143 - 1152. Retrieved 2018/09/10.
• 2、 Shin, Yongje,Yoo, Changho,Moon, Youngtaek,Lee, Yunho,Hong, Sungwoo. "Efficient synthesis of frutinone A and its derivatives through palladium-catalyzed C-H activation/carbonylation". . p. 878 - 881. Retrieved 2015/04/14.