Technology Process of (-)-2,3,3aS,8aR-tetrahydro-4-hydroxy-6-methoxy[2,3-d]-benzo[b]furan
There total 1 articles about (-)-2,3,3aS,8aR-tetrahydro-4-hydroxy-6-methoxy[2,3-d]-benzo[b]furan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: (R)-α,α-diphenyl-2-pyrrolidinemethanol derived catalyst / acetonitrile / 5 h / 20 °C
2.1: AcOH / 48 h / 110 °C
2.2: 40 percent / aq. H2SO4 / 1 h / 75 °C
3.1: 80 percent / DMAP; pyridine / CH2Cl2 / 2 h / 0 °C
4.1: tetrahydrofuran; diethyl ether / 2 h / -20 °C
5.1: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C
6.1: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C
7.1: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C
With
pyridine; dmap; (R)-α,α-diphenyl-2-pyrrolidinemethanol derived catalyst; hydrogen; urea hydrogen peroxide adduct; nickel; Dess-Martin periodane; acetic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;
5.1: Dess-Martin oxidation / 6.1: Baeyer-Villiger oxidation;
DOI:10.1021/ja054503m
- Guidance literature:
-
With
sodium hydrogencarbonate; zinc(II) carbonate;
In
dichloromethane;
at 20 ℃;
for 20h;
DOI:10.1021/ja054503m