Cromolyn

Base Information Edit

Chemical Name:Cromolyn
CAS No.:16110-51-3
Molecular Formula:C23H16O11
Molecular Weight:512.337
Hs Code.:2922499990
European Community (EC) Number:240-279-8
UNII:Y0TK0FS77W
DSSTox Substance ID:DTXSID4022860
Nikkaji Number:J9.027A
Wikipedia:Cromoglicic_acid
Wikidata:Q416427
NCI Thesaurus Code:C61691
RXCUI:42612
Pharos Ligand ID:3JSV1FQABGPF
Metabolomics Workbench ID:43249
ChEMBL ID:CHEMBL428880
Mol file:16110-51-3.mol

Synonyms:Aarane;Acid, Cromoglicic;Acid, Cromoglycic;Bicromat Spray;Cromoglicic Acid;Cromoglycate;Cromoglycate, Disodium;Cromoglycate, Sodium;Cromoglycic Acid;Cromolyn;Cromolyn Sodium;Disodium Cromoglycate;FPL 670;FPL-670;FPL670;Intal;Lomudal;Nalcrom;Nasalcrom;Opticrom;Sodium Cromoglycate;Vicrom

Suppliers and Price of Cromolyn

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylic acid) 95+%
250mg
$ 295.00

Matrix Scientific
5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylic acid) 95+%
1g
$ 495.00

Matrix Scientific
5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylic acid) 95+%
5g
$ 1475.00

CSNpharm
Cromolyn
100mg
$ 45.00

Crysdot
Cromolyn 95+%
10g
$ 103.00

Crysdot
Cromolyn 95+%
5g
$ 61.00

Crysdot
Cromolyn 95+%
25g
$ 206.00

Atlantic Research Chemicals
5,5''-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylicacid)(Cromolyn) 95%
250mgs:
$ 176.73

Atlantic Research Chemicals
5,5''-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylicacid)(Cromolyn) 95%
100mgs:
$ 127.24

American Custom Chemicals Corporation
CROMOLYN 95.00%
1G
$ 479.85

Total 75 raw suppliers

Chemical Property of Cromolyn Edit

Chemical Property:

Appearance/Colour:Solid
Vapor Pressure:1.08E-23mmHg at 25°C
Melting Point:241-242 °C
Refractive Index:1.681
Boiling Point:752.3 °C at 760 mmHg
PKA:pKa 2.0 (Uncertain)
Flash Point:263.9 °C
PSA：173.71000
Density:1.623 g/cm³
LogP:2.11450
Storage Temp.:2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:8
Exact Mass:468.06926132
Heavy Atom Count:34
Complexity:835

Purity/Quality:

99% ^*data from raw suppliers

5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylic acid) 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O
Recent ClinicalTrials:Cromoglicate Adjunctive Therapy for Outpatients With Schizophrenia
Recent EU Clinical Trials:A phase III Safety and Efficacy Study of ALZT-OP1 in Subjects with Evidence of Early Alzheimer’s Disease.
Description Cromolyn is a synthetic analog of the plant extract khellin that was first developed in the late 1960s and introduced into clinical practice the following decade. It is continued to be used widely in the treatment of allergic rhinitis, asthma, mastocytosis, and conjunctivitis. It has an outstanding safety profile and can be readily obtained without prescription in many countries.
Uses It is used for bronchial asthma, as well as prevention of seasonal, constant, and physically caused asthma attacks and allergic rhinitis. Cromolyn is used primarily for the prophylaxis of various types of asthma and in the treatment of allergic rhinitis, mastocytosis, and vernal conjunctivitis.
Therapeutic Function Bronchodilator
Clinical Use Cromolyn generally is used prophylactically for bronchial asthma (as an inhaled powder), for prevention of exercise-induced bronchospasm, and for seasonal and perennial allergic rhinitis (nasal solution). Topically, it also is used as eye drops for allergic conjunctivitis and keratitis. In the management of asthmatic conditions, it is administered using a power-operated nebulizer. The bioavailability is very low with oral administration because of poor absorption. By inhalation, the powder is irritating to some patients. After inhalation, much less than 10% of the dose reaches the systemic circulation. An oral dosage form is used for mastocytosis.

Technology Process of Cromolyn

There total 4 articles about Cromolyn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%