Benzidine hydrochloride

Base Information

• Chemical Name: Benzidine hydrochloride
• CAS No.: 531-85-1
• Molecular Formula: C12H12 N2 . 2 Cl H
• Molecular Weight: 257.163
• Hs Code.: 2921590090
• NSC Number: 3500
• UNII: 8CT94058SV
• DSSTox Substance ID: DTXSID80932239
• Wikidata: Q27270197
• Mol file: 531-85-1.mol

Synonyms:benzidine;benzidine acetate;benzidine dihydrochloride;benzidine hydrochloride;benzidine monosulfate

Chemical Property of Benzidine hydrochloride

Chemical Property:

• Appearance/Colour: WHITE TO OFF-WHITE POWDER
• Vapor Pressure: 2.5E-05mmHg at 25°C
• Melting Point: >300 ºC
• Boiling Point: 358.7°Cat760mmHg
• Flash Point: 203.5°C
• PSA: 52.04000
• Density: 1.156g/cm³
• LogP: 5.28440
• Water Solubility.: 0.1-0.5 g/100 mL at 23.5 ºC
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 220.0767261
• Heavy Atom Count: 15
• Complexity: 145

Purity/Quality:

98% or more ^*data from raw suppliers

Benzidine dihydrochloride ≥99% (titration) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,N,Xn
• Statements: 45-22-50/53-36/37/38-20/21/22
• Safety Statements: 53-45-60-61-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N.Cl
• Uses: The dihydrochlorie salt of Benzidine (B121000) a common used in dyes and environmental testing.

Technology Process of Benzidine hydrochloride

There total 2 articles about Benzidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p,p'-diaminobiphenyl (92-87-5) → benzidine dihydrochloride (531-85-1)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1039/b908490h

Reference yield:

N,N-dichloro-p-toluenesulfonamide (473-34-7) + chloroform (67-66-3,8013-54-5) + diphenyl hydrazine (122-66-7) → benzidine dihydrochloride (531-85-1) + toluene-4-sulfonamide (70-55-3) + trans-azobenzene (17082-12-1)

Guidance literature:

DOI:10.1021/ja01355a043

Reference yield: 77.0%

benzidine dihydrochloride (531-85-1) + 5-hydroxy-3-methyl-1-(pyrid-2-yl)-1H-pyrazole (38695-92-0) → C30H24N10O2

Guidance literature:

benzidine dihydrochloride; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃;

5-hydroxy-3-methyl-1-(pyrid-2-yl)-1H-pyrazole; With sodium hydroxide; aluminium trichloride; In water; for 0.5h; pH=8.0 - 8.5; cooling;

upstream raw materials:

N,N-dichloro-p-toluenesulfonamide

chloroform

diphenyl hydrazine

p,p'-diaminobiphenyl

Downstream raw materials:

4.4'-Biphenylen-diisocyanat

(1,1'-biphenyl)-4,4'-dicarbonitrile

4,4'-Bis-(phenyl-trans-azo)-biphenyl

1,1'-(4,4'-biphenylene)bis(3-phenylurea)

Refernces