Technology Process of 1-(((7,7-Dimethyl-2-(2-amino-4-(methylsulfonyl)butyramido)bicyclo(2.2.1)heptan-1-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine
There total 4 articles about 1-(((7,7-Dimethyl-2-(2-amino-4-(methylsulfonyl)butyramido)bicyclo(2.2.1)heptan-1-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 61 percent / H2 / W-2 Raney Ni / 2-methoxy-ethanol / 24 h / 2844.3 Torr
2: 98 percent / HOBT, EDC, diisopropylethylamine / dimethylformamide / 18 h
3: 98 percent / TFA / CH2Cl2 / 1 h
With
hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
W-2 Raney Ni;
In
dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 98 percent / HOBT, EDC, diisopropylethylamine / dimethylformamide / 18 h
2: 98 percent / TFA / CH2Cl2 / 1 h
With
benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
