C₂₂H₃₄N₂O₃S

Base Information

• Chemical Name: C₂₂H₃₄N₂O₃S
• CAS No.: 94853-23-3
• Molecular Formula: C₂₂H₃₄N₂O₃S
• Molecular Weight: 406.59
• Mol file: 94853-23-3.mol

Synonyms:C₂₂H₃₄N₂O₃S

Chemical Property of C₂₂H₃₄N₂O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₄N₂O₃S

There total 15 articles about C₂₂H₃₄N₂O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

rac-(1R,2S,5R,6R,8R)-2-Hydroxy-5-isopropyl-2,8-dimethyl-bicyclo<4.4.0>decan-7-on (2543-74-0,2767-20-6,20071-45-8,35124-31-3,35124-32-4,72243-95-9,94904-05-9,108715-30-6,121702-18-9,121702-29-2) + toluene-4-sulfonic acid hydrazide (1576-35-8) → C22H34N2O3S (94853-23-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; methanol; at 70 ℃; for 30h;

DOI:10.1016/S0040-4020(01)91500-5

Reference yield:

1-(2-Diethylaminoethoxy)-4-isopropyl-cyclohexadien-1,4 (80873-83-2) → C22H34N2O3S (94853-23-3)

Guidance literature:

Multi-step reaction with 15 steps

1: 1.) 15percent n-BuLi; 2.) Hexamethylphosphorsaeuretriamid / 1.) hexan, THF, -78 deg C, 2h; 2.) -73 deg C, 15 min; 3.) -78 deg C, 2h

2: 8 percent / aq. HCl / acetone / 24 h / Ambient temperature

3: 91 percent / 70percent Perchlorsaeure / CH₂Cl₂ / 0.75 h / Ambient temperature

4: 84 percent / 5percent KOH / methanol / 0.75 h / 0 °C

5: 93 percent / diethyl ether / 1.75 h / -78 °C

6: Spur Sudan III, O₃; 2.) Zn / 1.) acetic acid, ethyl acetate, -78 deg C; 2.) RT, 1h

7: 77 percent / m-Chloperbenzoesaeure / CH₂Cl₂ / 192 h / 50 °C

8: 90 percent / 5percent KOH / methanol / 1 h / 0 °C

9: 80 percent / CrO₃, H₂SO₄ / acetone / 0.08 h / 0 °C

10: 77 percent / Diisopropylethylamin / CH₂Cl₂ / 48 h / Ambient temperature

11: 97 percent / 5percent KOH / methanol / 3 h / 0 °C

12: 83 percent / CrO₃, H₂SO₄ / acetone / 0.08 h / 0 °C

13: 1.) Diisopropylamin, 15percent n-Butyllithium / 1.) THF, hexan, -78 deg C, 15 min; 2.) -78 deg C, 1h, THF; 3.) 0 deg C 1h, RT, 12h

14: 87 percent / 1percent HCl / tetrahydrofuran; methanol / 30 h / 65 °C

15: 38 percent / 1percent HCl / tetrahydrofuran; methanol / 30 h / 70 °C

With chromium(VI) oxide; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; n-butyllithium; perchloric acid; sulfuric acid; ozone; diisopropylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; zinc; Sudan III; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone;

DOI:10.1016/S0040-4020(01)91500-5

Reference yield:

rac-(1R,2S,5R,6R)-2-Hydroxy-5-isopropyl-2-methyl-bicyclo<4.4.0>decan-7-on (94853-18-6) → C22H34N2O3S (94853-23-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 77 percent / Diisopropylethylamin / CH₂Cl₂ / 48 h / Ambient temperature

2: 97 percent / 5percent KOH / methanol / 3 h / 0 °C

3: 83 percent / CrO₃, H₂SO₄ / acetone / 0.08 h / 0 °C

4: 1.) Diisopropylamin, 15percent n-Butyllithium / 1.) THF, hexan, -78 deg C, 15 min; 2.) -78 deg C, 1h, THF; 3.) 0 deg C 1h, RT, 12h

5: 87 percent / 1percent HCl / tetrahydrofuran; methanol / 30 h / 65 °C

6: 38 percent / 1percent HCl / tetrahydrofuran; methanol / 30 h / 70 °C

With chromium(VI) oxide; hydrogenchloride; potassium hydroxide; n-butyllithium; sulfuric acid; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1016/S0040-4020(01)91500-5

upstream raw materials:

rac-(1R,2S,5R,6R,8R)-2-Hydroxy-5-isopropyl-2,8-dimethyl-bicyclo<4.4.0>decan-7-on

toluene-4-sulfonic acid hydrazide

1-(2-Diethylaminoethoxy)-4-isopropyl-cyclohexadien-1,4

rac-(1R,2S,5R,6R)-2-Hydroxy-5-isopropyl-2-methyl-bicyclo<4.4.0>decan-7-on

Downstream raw materials:

(±)-torreyol

Refernces