Thiopental

Base Information Edit

Chemical Name:Thiopental
CAS No.:76-75-5
Deprecated CAS:59709-53-4
Molecular Formula:C11H18 N2 O2 S
Molecular Weight:242.342
Hs Code.:2933595960
European Community (EC) Number:200-984-3,200-763-1
UNII:JI8Z5M7NA3
DSSTox Substance ID:DTXSID1023653
Nikkaji Number:J10.978I
Wikipedia:Sodium_thiopental
Wikidata:Q55186498
NCI Thesaurus Code:C72166
Pharos Ligand ID:WF6BQV3P7B26
Metabolomics Workbench ID:42929
ChEMBL ID:CHEMBL441
Mol file:76-75-5.mol

Synonyms:Bomathal;Nesdonal;Penthiobarbital;Pentothal;Pentothal Sodico;Sodipental;Thiomebumal;Thionembutal;Thiopental;Thiopental Nycomed;Thiopental Sodium;Thiopentobarbital;Thiopentone;Tiobarbital Braun;Trapanal

Suppliers and Price of Thiopental

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Thiopental
100mg
$ 370.00

Sigma-Aldrich
(±)Thiopental solution 1.0mg/mL in methanol, analytical standard, for drug analysis
1ml
$ 127.00

Sigma-Aldrich
(±)-Thiopental
10mg
$ 62.00

Sigma-Aldrich
Thiopental United States Pharmacopeia (USP) Reference Standard
250mg
$ 465.00

American Custom Chemicals Corporation
THIOPENTAL 95.00%
2.5G
$ 1683.00

American Custom Chemicals Corporation
THIOPENTAL 95.00%
250MG
$ 704.55

AHH
(+/-)-Thiopental 98%
10ml
$ 400.00

Total 58 raw suppliers

Chemical Property of Thiopental Edit

Chemical Property:

Appearance/Colour:Off-White Solid
Melting Point:158-160°C
Refractive Index:1.5440 (estimate)
PKA:7.11±0.40(Predicted)
Flash Point:11℃
PSA：90.29000
Density:1.16g/cm³
LogP:2.00750
Storage Temp.:2-8°C
Solubility.:ethanol: complete50mg/mL
Water Solubility.:50mg/L(25 oC)
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:242.10889899
Heavy Atom Count:16
Complexity:308

Purity/Quality:

99.9% ^*data from raw suppliers

Thiopental ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,T,F
Hazard Codes:Xn,T,F
Statements: 22-39/23/24/25-23/24/25-11
Safety Statements: 36/37/39-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCC(C)C1(C(=O)NC(=S)NC1=O)CC
Recent ClinicalTrials:Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
Recent EU Clinical Trials:Propofol and thiopental for intravenous induction in neonates: a dose finding study
Recent NIPH Clinical Trials:Comparison of hemodynamic changes between propofol and thiopental during general anesthesia induction
Uses A thio-derivative of Barbituric acid. Controlled substance (depressant). Anesthetic
Therapeutic Function Narcotic analgesic, Anesthetic

Technology Process of Thiopental

There total 11 articles about Thiopental which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 57-33-0
nembutal

: 76-75-5,20224-43-5,21045-47-6
thiopentone

Guidance literature:: nembutal; With hydrogenchloride; In dichloromethane; at 20 ℃; for 0.166667h;

With Lawessons reagent; methoxybenzene; for 150h; Reflux;
DOI:10.1074/jbc.M116.766964