Metapramine

Base Information

• Chemical Name: Metapramine
• CAS No.: 21730-16-5
• Molecular Formula: C₁₆H₁₈N₂
• Molecular Weight: 238.332
• Hs Code.: 2933990090
• UNII: 303954M7YF
• DSSTox Substance ID: DTXSID60865011
• Nikkaji Number: J11.156B
• Wikipedia: Metapramine
• Wikidata: Q15409392
• NCI Thesaurus Code: C87617
• ChEMBL ID: CHEMBL2106919
• Mol file: 21730-16-5.mol

Synonyms:15-methyl-10-methylamino-10,11- dihydrodibenzo(b,f)-azepine;19560 RP;19560-RP;metapramine

Chemical Property of Metapramine

Chemical Property:

• Vapor Pressure: 4.27E-05mmHg at 25°C
• Melting Point: 237-240 °C
• Boiling Point: 350.8°Cat760mmHg
• PKA: 9.09±0.20(Predicted)
• Flash Point: 140.7°C
• PSA: 15.27000
• Density: 1.12g/cm³
• LogP: 3.72700
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 238.146998583
• Heavy Atom Count: 18
• Complexity: 278

Purity/Quality:

95-99% ^*data from raw suppliers

Metapramine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1CC2=CC=CC=C2N(C3=CC=CC=C13)C
• Description: Metapramine is an antidepressant with a pharmacological profile similar to the tricyclics and an apparent rapid clinical onset of action. Metapramine differs biochemically from the tricyclics in that it markedly enhances norepinephrine turnover with minimal inhibition of reuptake. Like the tricyclics, however, it does down regulate β-receptors.
• Uses: Metapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine.
• Therapeutic Function: Antidepressant

Technology Process of Metapramine

There total 1 articles about Metapramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ metapramine (21730-16-5)

Guidance literature:

10-Carbamido-benzazepin VII, LiAlH4;