N-(2-bromophenyl)tetrahydro-2-furancarboxamide

Base Information

• Chemical Name: N-(2-bromophenyl)tetrahydro-2-furancarboxamide
• CAS No.: 349081-60-3
• Molecular Formula: C₁₁H₁₂BrNO₂
• Molecular Weight: 270.126
• Mol file: 349081-60-3.mol

Synonyms:N-(2-bromophenyl)tetrahydro-2-furancarboxamide

Chemical Property of N-(2-bromophenyl)tetrahydro-2-furancarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromophenyl)tetrahydro-2-furancarboxamide

There total 1 articles about N-(2-bromophenyl)tetrahydro-2-furancarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tetrahydro-2-furancarboxylic acid (16874-33-2) + 2-bromoaniline (615-36-1) → N-(2-bromophenyl)tetrahydro-2-furancarboxamide (349081-60-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1055/s-2005-871563

Reference yield: 86.0%

allyl bromide (106-95-6) + N-(2-bromophenyl)tetrahydro-2-furancarboxamide (349081-60-3) → tetrahydro-furan-2-carboxylic acid allyl-(2-bromo-phenyl)-amide (866456-25-9)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1055/s-2005-871563

Reference yield:

propargyl bromide (106-96-7) + N-(2-bromophenyl)tetrahydro-2-furancarboxamide (349081-60-3) → tetrahydro-furan-2-carboxylic acid (2-bromo-phenyl)-prop-2-ynyl-amide (866456-53-3)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1055/s-2005-871563

upstream raw materials:

tetrahydro-2-furancarboxylic acid

2-bromoaniline

Downstream raw materials:

tetrahydro-furan-2-carboxylic acid allyl-(2-bromo-phenyl)-amide

tetrahydro-furan-2-carboxylic acid (2-bromo-phenyl)-prop-2-ynyl-amide

Refernces

• 1、 Lee,Hartwig. "Improved catalysts for the palladium-catalyzed synthesis of oxindoles by amide α-arylation. Rate acceleration, use of aryl chloride substrates, and a new carbene ligand for asymmetric transformations". . p. 3402 - 3415. Retrieved 2007/10/03.