Pyridin-3-ylmethanamine Hydrochloride

Base Information

• Chemical Name: Pyridin-3-ylmethanamine Hydrochloride
• CAS No.: 84359-15-9
• Molecular Formula: C6H8N2
• Molecular Weight: 144.604
• NSC Number: 194312
• DSSTox Substance ID: DTXSID70383135
• Mol file: 84359-15-9.mol

Synonyms:Pyridin-3-ylmethanamine Hydrochloride;84359-15-9;3-(aminomethyl)pyridine hydrochloride;C-Pyridin-3-yl-methylamine hydrochloride;SCHEMBL2674094;DTXSID70383135;Pyridin-3-ylmethanamineHydrochloride;NSC194312;pyridin-3-ylmethanamine;hydrochloride;AKOS000320648;NSC-194312;SB54108;AM101339

Chemical Property of Pyridin-3-ylmethanamine Hydrochloride

Chemical Property:

• Vapor Pressure: 0.0838mmHg at 25°C
• Boiling Point: 226°C at 760 mmHg
• Flash Point: 100.6°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 144.0454260
• Heavy Atom Count: 9
• Complexity: 63.5

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CN=C1)CN.Cl

Technology Process of Pyridin-3-ylmethanamine Hydrochloride

There total 2 articles about Pyridin-3-ylmethanamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.7%

3-pyridinecarboxaldehyde (500-22-1) → 3-(aminomethyl)pyridine dihydrochloride (22199-21-9,29968-85-2,84359-15-9)

Guidance literature:

3-pyridinecarboxaldehyde; With pyridoxal 5'-phosphate; ω-transaminase from Bacillus megaterium; isopropylamine; for 24h; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; Reagent/catalyst;

DOI:10.1002/adsc.202100997

Reference yield:

3-chloromethylpyridinium chloride (6959-48-4) → bis(pyridin-3-ylmethyl)amine (1656-94-6) + (pyridin-3-yl)methylamine hydrochloride (84359-15-9)

Guidance literature:

With ammonia; In methanol; at 130 ℃; for 0.5h; microwave irradiation;

DOI:10.1016/j.tetlet.2003.10.146

Reference yield: 61.0%

ethyl 3-(5-(cis-3-isopropyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2-methoxyphenyl)propiolate + (pyridin-3-yl)methylamine hydrochloride (84359-15-9) → 3-(5-(cis-3-isopropyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2-methoxyphenyl)-N-(pyridin-3-ylmethyl)propiolamide

Guidance literature:

With trimethylaluminum; triethylamine hydrochloride; potassium carbonate; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2019.06.026

upstream raw materials:

3-pyridinecarboxaldehyde

3-chloromethylpyridinium chloride

Refernces

• 1、 Saulnier, Mark G.,Zimmermann, Kurt,Struzynski, Charles P.,Sang, Xiaopeng,Velaparthi, Upender,Wittman, Mark,Frennesson, David B.. "Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol". . p. 397 - 399. Retrieved 2007/10/03.