Anagrelide

Base Information

• Chemical Name: Anagrelide
• CAS No.: 68475-42-3
• Molecular Formula: C10H7Cl2N3O
• Molecular Weight: 256.091
• Hs Code.: 2933990090
• Mol file: 68475-42-3.mol

Synonyms:6,7-Dichloro-1,5-dihydroimidazo[2,1-β]quinazolin-2(3H)-one;Anagrelide;Xagrid;

Chemical Property of Anagrelide

Chemical Property:

• Vapor Pressure: 7.21E-06mmHg at 25°C
• Melting Point: 280 °C
• Refractive Index: 1.79
• Boiling Point: 376.5 °C at 760 mmHg
• PKA: pKa 2.87 (H2O t=25 I=0.025) (Uncertain);10(H2O t=25 I=0.025) (Uncertain)
• Flash Point: 181.5 °C
• PSA: 44.70000
• Density: 1.77 g/cm³
• LogP: 1.62860
• Storage Temp.: 2-8°C
• Water Solubility.: slightly soluble

Purity/Quality:

99%min ^*data from raw suppliers

Anagrelide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: the treatment of primary thrombocytosis Anagrelide; Potent PDE 3 inhibitorIt can be used to inhibit cancer cell invasion.
• Clinical Use: Platelet-reducing agent
• Drug interactions: Potentially hazardous interactions with other drugs Aspirin: potential risks and benefits must first be assessed, additive antiplatelet effect. Cilostazol: avoid concomitant use. Grapefruit juice: may reduce clearance of anagrelide. Phosphodiesterase inhibitors: avoid with milrinone and enoximone.

Technology Process of Anagrelide

There total 21 articles about Anagrelide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

anagrelide hemiformate → anagrelide (68475-42-3)

Guidance literature:

With water; In ethanol; at 23 ℃; for 3h;

Reference yield: 88.0%

→ anagrelide (68475-42-3)

Guidance literature:

Reference yield: 80.0%

ethyl (2?amino?5,6?dichloroquinazoline?3(4H)?yl)acetate → anagrelide (68475-42-3)

Guidance literature:

ethyl (2?amino?5,6?dichloroquinazoline?3(4H)?yl)acetate; With sodium hydrogencarbonate; In ethanol; at 20 ℃; for 1h; pH=8 - 9;

With sodium hydroxide; In ethanol; at 4 - 20 ℃; for 1.5h; pH=10 - 11;

upstream raw materials:

ethyl-(2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl) acetate

(2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl) acetonitrile

(2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)-acetonitrile

ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)-acetate

Downstream raw materials:

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

anagrelide hydrochloride

Refernces

• 1、 -. "PROCESS FOR MAKING ANAGRELIDE". Page/Page column 11. . Retrieved 2015/01/16.
• 2、 -. "PROCESS FOR THE PREPARATION OF ETHYL-N-(2, 3-DICHLORO-6-NITROBENZYL) GLYCINE HYDROCHLORIDE". Page/Page column 14. . Retrieved 2008/12/08.